High-intensity Interval Versus Combined Exercise Training in CHF

NCT ID: NCT02387411

Last Updated: 2015-03-13

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 30 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2010-05-31
• Study Completion Date: 2015-06-30

Brief Summary

Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.

Conditions

Heart Failure

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Interval group

high-intensity interval exercise training

Group Type: ACTIVE_COMPARATOR

High-intensity interval exercise training

Intervention Type: OTHER

High-intensity interval exercise training \[4 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\]

Combined group

combined exercise training

Group Type: ACTIVE_COMPARATOR

Combined exercise training

Intervention Type: OTHER

High intensity \[2 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\] and strength exercise training (2-4 sets, 10-12 reps, 60-65% 1RM, for quadriceps and hamstrings, 14 min in total)

Interventions

High-intensity interval exercise training

High-intensity interval exercise training \[4 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\]

Intervention Type: OTHER

Combined exercise training

High intensity \[2 reps \* (4 min at 80% VO2peak + 3 min at 50% VO2peak)\] and strength exercise training (2-4 sets, 10-12 reps, 60-65% 1RM, for quadriceps and hamstrings, 14 min in total)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• stable heart failure
• ejection fraction <=45%
• optimal medical treatment
• NYHA class <=III

Exclusion Criteria

• contraindications for maximal cardiopulmonary exercise testing (CPET)
• moderate to severe COPD
• inability to follow exercise programs due to orthopaedic problems

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

University of Athens

OTHER

Sponsor Role: lead

Responsible Party

Serafim Nanas

Prof Critical Care Medicine

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Serafim Nanas, MD, Prof.

Role: STUDY_CHAIR

Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens, Greece

Locations

Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens

Athens, , Greece

Countries

Greece

References

Tryfonos A, Tzanis G, Karatzanos Epsilon, Koutsilieris M, Nanas S, Philippou A. Inflammation- and Tissue Remodeling-Related Gene Responses in Skeletal Muscle of Heart Failure Patients Following High-Intensity Interval Training. Rev Cardiovasc Med. 2023 Feb 6;24(2):46. doi: 10.31083/j.rcm2402046. eCollection 2023 Feb.

Reference Type: DERIVED

PMID: 39077398 (View on PubMed)

Alshamari M, Kourek C, Sanoudou D, Delis D, Dimopoulos S, Rovina N, Nanas S, Karatzanos E, Philippou A. Does the Addition of Strength Training to a High-Intensity Interval Training Program Benefit More the Patients with Chronic Heart Failure. Rev Cardiovasc Med. 2023 Jan 16;24(1):29. doi: 10.31083/j.rcm2401029. eCollection 2023 Jan.

Reference Type: DERIVED

PMID: 39076879 (View on PubMed)

Tryfonos A, Tzanis G, Pitsolis T, Karatzanos E, Koutsilieris M, Nanas S, Philippou A. Exercise Training Enhances Angiogenesis-Related Gene Responses in Skeletal Muscle of Patients with Chronic Heart Failure. Cells. 2021 Jul 28;10(8):1915. doi: 10.3390/cells10081915.

Reference Type: DERIVED

PMID: 34440684 (View on PubMed)

Other Identifiers

not applied

Identifier Type: -

Identifier Source: org_study_id