Skeletal Muscle Dysfunction in Heart Failure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Brief Summary

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Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.

We hypothesize that congestive heart failure has systemic effects that causes the skeletal muscle dysfunction.

Detailed Description

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Conditions

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Heart Failure, Congestive

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

ECT

Blinding Strategy

SINGLE

Interventions

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One-knee extension ergometer

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Coronary Heart Failure
* Ejection fraction \<35%
* NYHA 2-3
* Spirometry FEV1 \> 80%

Exclusion Criteria

* Cardiomyopathy
* Transplantation candidate
* Active malignancy
* Restraining skeletal-muscular disease
* Claudication in legs
* Hospitalized last 30 days due to acute ischemic episode
* Intravenous inotrope or vasodilatating drugs last 14 days prior to inclusion
* AMI last 8 weeks prior to inclusion
* Organized training last 4 months
* Smoking on daily basis last 4 months
* Creatinin \< 150microliters/liter

Minimum Eligible Age

40 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes