Role of Endothelial Function, Muscular Fitness and Metabolism in Functional Activity in Patients With Chronic Heart Failure (CHF)

NCT ID: NCT01139086

Last Updated: 2010-06-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-05-31

Study Completion Date

2011-05-31

Brief Summary

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Shortness of breath, fatigue, and exercise intolerance are clinical symptoms of chronic heart failure (CHF). Recent studies suggested that peripheral impairment was the major cause of clinical symptoms, and mechanism may be related to neuroendocrine impairment and vascular smooth muscle dysfunction. It results in increased peripheral resistance that may influence limb blood flow, muscle fitness and activities of daily.The purposes of this study are

1. to compare muscular strength, endurance, and perfusion of quadriceps between CHF patients and healthy controls by isokinetic test and near-infrared spectroscopy (NIRS) and difference in activities of daily living
2. to compare endothelium function between CHF patients and healthy control subjects
3. the relationship between endothelium function, muscular strength, endurance, perfusion, and metabolism of quadriceps.

Detailed Description

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Conditions

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Chronic Heart Failure Coronary Disease Dilated Cardiomyopathy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Cardiovascular disease

Diagnosis of cardiomyopathy or ischemic heart disease without heart failure

No interventions assigned to this group

Chronic heart failure

Diagnosis of cardiomyopathy or ischemic heart disease LVEF \<40%

No interventions assigned to this group

Control

Age and body built matched with chronic heart failure group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age 40-75 years
* Chronic heart failure: ejection fraction\<40% and at stable condition
* Coronary Disease and dilated cardiomyopathy without heart failure
* Control group without diagnosis of any heart disease

Exclusion Criteria

* Clinical diagnosis of neuromusculoskeletal , pulmonary, or other systemic diseases that may affect the testing of the study
Minimum Eligible Age

40 Years

Maximum Eligible Age

75 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University

Principal Investigators

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Ying-Tai Wu, Ph.D

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Ying-Tai Wu, Ph.D

Role: CONTACT

+886-2-33668129

Facility Contacts

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Ying-Tai Wu, Ph. D

Role: primary

886-2-33668129

Other Identifiers

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201003050R

Identifier Type: -

Identifier Source: org_study_id

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