The Effect of Small Changes in Hydration on Cognition

NCT ID: NCT02671149

Last Updated: 2020-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

101 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2016-03-31

Brief Summary

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The aim of this study is to determine whether drinking plain water when mildly dehydrated benefits cognitive performance and mood. Volunteers undergo a dehydration protocol designed to result in minor dehydration. While some participants receive two 150ml drinks of water others do not. Differences in cognitive functioning are assessed.

Detailed Description

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As an essential nutrient, an inadequate intake of water has negative consequences: without a source of water death will occur in days. When Benton and Young (2015) reviewed the topic they concluded that in healthy adults, mild dehydration (in the range of a loss of 2% body mass) had been found to adversely influence mood and cognition. However, it is unclear at what degree of hypohydration these effects begin to emerge.

This study was designed to determine whether small changes in hydration, of the level that might occur on a day to day basis, influence cognition and mood. During a dehydration protocol (sitting in a room heated to 30 degrees for four hours) young adult participants receive either drink two 150ml cups of water or nothing. Effects on memory, attention and mood are monitored.

Conditions

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Cognition Hydration

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Participants

Study Groups

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Drink water

Participants will receive two 150ml drinks of water during the dehydration protocol

Group Type EXPERIMENTAL

Water

Intervention Type DIETARY_SUPPLEMENT

Participants will receive two cups of 150ml plain water

Drink nothing

Participants will drink nothing during the dehydration protocol

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Water

Participants will receive two cups of 150ml plain water

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* In good general health i.e. no major health condition such as diabetes
* BMI \< 30

Exclusion Criteria

* Not on blood pressure medication or blood thinning medication such as aspirin - No learning difficulty such as dyslexia
* Diabetes
* Gastro-intestinal disease
* High BMI
* Cholesterol and BP
* Smoker
* Dyslexic/dyspraxic
* Depression or history of depression or other psychiatric disorder
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Swansea University

OTHER

Sponsor Role lead

Responsible Party

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Dr Hayley Young

Dr

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Swansea University

Swansea, West Glamorgan, United Kingdom

Site Status

Countries

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United Kingdom

References

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Benton D, Young HA. Do small differences in hydration status affect mood and mental performance? Nutr Rev. 2015 Sep;73 Suppl 2:83-96. doi: 10.1093/nutrit/nuv045.

Reference Type BACKGROUND
PMID: 26290294 (View on PubMed)

Benton D, Jenkins KT, Watkins HT, Young HA. Minor degree of hypohydration adversely influences cognition: a mediator analysis. Am J Clin Nutr. 2016 Sep;104(3):603-12. doi: 10.3945/ajcn.116.132605. Epub 2016 Aug 10.

Reference Type DERIVED
PMID: 27510536 (View on PubMed)

Other Identifiers

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HYD01

Identifier Type: -

Identifier Source: org_study_id

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