The Effects of Hydration on Gut Health and Thinking

NCT ID: NCT05315531

Last Updated: 2024-01-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-08-23
• Study Completion Date: 2022-07-29

Brief Summary

The central hypothesis is that improving hydration through increased water consumption will change the relative abundance of mucolytic bacteria found in the stool. Therefore the specific aims are 1) to quantify intervention effects on fecal microbiota relative abundance and plasma lipopolysaccharide binding protein, 2) observe the effects of the intervention on bowel frequency and signs/symptoms of gastrointestinal stress, and 3) to investigate relations between executive function and hydration status.

Detailed Description

A single arm 3-week hydration intervention will be employed where participants increase their water consumption to 2 (F) or 2.5(M) liters per day which is approximately 70% of the AI for daily water consumption. Pre-test and follow-up measures of fecal microbiota, urinary hydration status, cognitive function, circulating markers, and dietary intake will be assessed at baseline and at 3-week follow up via laboratory visits.

Conditions

Dehydration; Cognitive Change; Gastrointestinal Microbiota

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: PREVENTION
• Blinding Strategy: NONE

Study Groups

Water Intake

3-week intervention period during which articipants will be asked to increase their daily plain water consumption to at least 2.5 L/d of water for males and 2L/d for females.

Group Type: EXPERIMENTAL

Water Intake

Intervention Type: DIETARY_SUPPLEMENT

Participants will increase plain water consumption to at least 70% of the daily adequate intake for Americans depending on their sex.

Interventions

Water Intake

Participants will increase plain water consumption to at least 70% of the daily adequate intake for Americans depending on their sex.

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

• 19-50 years of age
• 18.5-34.49 kg/m2
• 24-hour UOsm above 500 mOsm/kg
• No antibiotic use over the past 3 months
• Absence of metabolic diseases and use of diuretics
• Agree to maintain typical diet intake (e.g., dietary fiber) patterns during intervention
• Avoid consuming prebiotic and probiotic supplements during study participation
• Not pregnant
• Agree to follow the study protocol

Exclusion Criteria

• <19 or >50 years of age
• <18.5 or >34.49 kg/m2
• 24-hour UOsm <500 mOsm/kg
• Antibiotic use over the past 3 months
• Metabolic diseases and use of diuretics
• Not agree to maintain typical diet intake (e.g., dietary fiber) patterns for the duration of the
• intervention
• Not agree with avoiding consuming prebiotic and probiotic supplements during study participation
• Pregnant
• Not agree to follow study protocol

• Minimum Eligible Age: 19 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign

UNKNOWN

Sponsor Role: collaborator

University of Illinois at Urbana-Champaign

OTHER

Sponsor Role: lead

Responsible Party

Naiman Khan

Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

University of Illinois at Urbana-Champaign

Urbana, Illinois, United States

Countries

United States

Other Identifiers

WatUP

Identifier Type: -

Identifier Source: org_study_id