Does Salt Intake Improve Mood

NCT ID: NCT03467568

Last Updated: 2018-03-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-01-01

Study Completion Date

2018-04-01

Brief Summary

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Humans display a preference for salt although the reasons remain unclear. The aim was to examine the hypothesis that salt may enhance mood. The study compares the drinking of water with and without electrolytes (either dissolved in water or by capsule). Mood was rated over a period of 155 minutes

Detailed Description

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Study 1. 120 young adults will be were recruited. They will arrive in the laboratory at 0900 having consumed their normal breakfast. Over the morning they will reported their mood by responding to one hundred millimetre visual analogue scales anchored with the words: Composed/Anxious; Hostile/Agreeable; Elated/Depressed; Unsure/Confident; Energetic/Tired; Confused/Clearheaded. These dimensions of mood came from the factor analysis that formed the basis of the Profile of Mood State questionnaire. An overall measure of mood will be calculated. .

Randomly they will receive either a 150ml glass of water, or an equivalent volume of water containing electrolytes (in total 150mg sodium chloride and 45mg potassium chloride (Gatorade G2 Low calorie (34 kcal) Thirst Quencher, Pepsico). This drink will be consumed for a first time after 50 minutes, and a second time after 140 minutes. A estimate of habitual salt preference will be gained by responding to questions concerning the adding of salt to meals and a preference for salty foods.

Study 2: One hundred and twenty young adults will be recruited. A second study attempts to replicate the first in a double-blind trial where the taste of salt was hidden by using a capsule. . Participants will be assigned to one of four experimental conditions; 1) swallowed placebo capsules; 2) swallowed capsules containing electrolyte (300mg sodium chloride); 3) received placebo capsules and plain water; 4) received capsules containing electrolyte and plain water. Each drink will be 150ml of water. The allocation of the type of capsule will be carried out double-blind, determined by computer generated random numbers.

Otherwise the procedure will be identical to study one.

Conditions

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Mood Salt Intake

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The study has four arms. Salt alone; salt plus water; placebo alone, placebo plus water
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators
Salt / placebo will be consumed by capsule under a double blind procedure

Study Groups

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Sodium chloride / Water

The sodium chloride / water arm involves 300mg sodium chloride being consumed in a capsule and on two occasions 150ml of water being drunk

Group Type ACTIVE_COMPARATOR

Sodium Chloride

Intervention Type DIETARY_SUPPLEMENT

300mg sodium chloride will be provided in a capsule

Water

Intervention Type DIETARY_SUPPLEMENT

Twice during the morning a drink of 150ml of water will be consumed

Sodium chloride / no water

A capsule containing 300mg of sodium chloride will be consumed but no water will be drunk over the morning

Group Type ACTIVE_COMPARATOR

Sodium Chloride

Intervention Type DIETARY_SUPPLEMENT

300mg sodium chloride will be provided in a capsule

No water consumed

Intervention Type BIOLOGICAL

No water will be consumed during the monring

Placebo / water

A capsule containing a placebo will be consumed and on two occasions 150ml of water will be drunk

Group Type ACTIVE_COMPARATOR

Placebo capsule

Intervention Type OTHER

A capsule of identical appearance to that providing salt, but not containing electrolytes, will be consumed

Water

Intervention Type DIETARY_SUPPLEMENT

Twice during the morning a drink of 150ml of water will be consumed

Placebo / no water

A capsule containing a placebo will be consumed but no water will be drunk over the morning

Group Type PLACEBO_COMPARATOR

Placebo capsule

Intervention Type OTHER

A capsule of identical appearance to that providing salt, but not containing electrolytes, will be consumed

No water consumed

Intervention Type BIOLOGICAL

No water will be consumed during the monring

Interventions

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Sodium Chloride

300mg sodium chloride will be provided in a capsule

Intervention Type DIETARY_SUPPLEMENT

Placebo capsule

A capsule of identical appearance to that providing salt, but not containing electrolytes, will be consumed

Intervention Type OTHER

Water

Twice during the morning a drink of 150ml of water will be consumed

Intervention Type DIETARY_SUPPLEMENT

No water consumed

No water will be consumed during the monring

Intervention Type BIOLOGICAL

Eligibility Criteria

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Exclusion Criteria

\-
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Swansea University

OTHER

Sponsor Role lead

Responsible Party

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David Benton

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Psychology, Swansea University

Swansea, Wales, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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David Benton, DSc

Role: CONTACT

++441792295607

Hayley Young, PhD

Role: CONTACT

++441792295908

Facility Contacts

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Hayley Young, PhD

Role: primary

++44 1792 295607

David Benton, DSc

Role: backup

++44 1792 295607

Other Identifiers

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DB-0123-SALT

Identifier Type: -

Identifier Source: org_study_id

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