Effect of Daily Vinegar Ingestion for Four Weeks on Mood State in Healthy College Students

NCT ID: NCT04706806

Last Updated: 2021-01-13

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 25 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-09-29
• Study Completion Date: 2020-11-17

Brief Summary

The objective of this research is to record mood states and depression levels in healthy college students before and after 4 weeks of daily vinegar ingestion.

Detailed Description

Recent research suggests that fruit and vegetable intake is inversely associated with mood states and depression. Although the mechanism is not known, increased gut fermentation is suspected as changes in gut tryptophan metabolism was noted in these trials. Tryptophan is the precursor to serotonin, the neurotransmitter associated with improved mood state, but other metabolites of tryptophan have been associated with mental wellbeing as well. The main ingredient of vinegar, acetic acid, is the most common metabolite produced during gut fermentation of dietary fiber (mainly from fruits and vegetables) and can also be expected to influence the gut microbiome. It has been reported that vinegar ingestion is linked to a change in tryptophan metabolism in healthy adults consuming vinegar daily for 8 weeks. This study will explore the impact of vinegar ingestion on mood states.

Conditions

Mood; Depression

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: SINGLE

Study Groups

liquid vinegar

2 tablespoons (diluted in water) taken twice daily with meals

Group Type: EXPERIMENTAL

apple cider vinegar

Intervention Type: DIETARY_SUPPLEMENT

2 tablespoons diluted in water taken twice daily with meals

vinegar pill

1 vinegar pill taken daily

Group Type: PLACEBO_COMPARATOR

vinegar pill

Intervention Type: DIETARY_SUPPLEMENT

one pill taken daily

Interventions

apple cider vinegar

2 tablespoons diluted in water taken twice daily with meals

Intervention Type: DIETARY_SUPPLEMENT

vinegar pill

one pill taken daily

Intervention Type: DIETARY_SUPPLEMENT

Other Intervention Names

apple cider vinegar (Bragg Live Food Products, LLC); Nature's Bounty Apple Cider Vinegar pills

Eligibility Criteria

Inclusion Criteria

• college student, non-athlete, no chronic health condition

Exclusion Criteria

• vegetarians or others adhering to special diet, body mass index >30 kg/m2, pregnancy/lactation, unwilling to ingest vinegar

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Arizona State University

OTHER

Sponsor Role: lead

Responsible Party

Carol Johnston

Professor and Associate Dean

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Arizona State University

Phoenix, Arizona, United States

Countries

United States

Other Identifiers

STUDY00012406

Identifier Type: -

Identifier Source: org_study_id