Tea Consumption and Cognitive Performance in the Very Old

NCT ID: NCT03278743

Last Updated: 2017-09-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 1042 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2006-06-30
• Study Completion Date: 2013-03-31

Brief Summary

Studies have found a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old defined as individuals aged 85 years and over. Therefore, we hypothesized that higher tea consumption was associated with better global and domain-specific cognitive function. We investigated the relationship between tea consumption in the very old and measures of global cognitive function, memory, attention and psychomotor speed.

The Newcastle 85+ Study was a longitudinal (5-years), population-based cohort study of individuals aged 85+ years in North East England, United Kingdom. The final sample included 676 community-dwelling and institutionalized men and women recruited through general medical practices.

Baseline tea consumption was assessed through a 2x24-hr multiple pass recall and longitudinal measures of global and domain specific (memory, speed and attention) cognitive function through the standardized mini-mental state examination and the cognitive drug research system. Linear mixed models, controlling for demographic (e.g. age, sex and education) and health variables were used to determine whether tea consumption was protective against cognitive decline.

Conditions

Cognition

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

low to moderate tea consumption

consumption of 0.4 to 4.6 cups of tea (200 ml) per day (n=463)

Cognitive performance and cognitive decline

Intervention Type: OTHER

Assess the global and domain specific (memory, speed and attention) cognitive function at baseline and over 5 years in the high vs. low/moderate tea consumption groups

High tea consumption

consumption of 4.6 to 11.9 cups of tea (200 ml) per day (n=213)

Cognitive performance and cognitive decline

Intervention Type: OTHER

Assess the global and domain specific (memory, speed and attention) cognitive function at baseline and over 5 years in the high vs. low/moderate tea consumption groups

Interventions

Cognitive performance and cognitive decline

Assess the global and domain specific (memory, speed and attention) cognitive function at baseline and over 5 years in the high vs. low/moderate tea consumption groups

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Born in 1921
• Permanently registered with a participating general practice in Newcastle upon Tyne or North Tyneside primary care trusts in the UK

Exclusion Criteria

• End-stage illness
• Individuals who might pose a safety risk to a nurse visiting alone, with dementia
• Clinical diagnosis of dementia at baseline

• Minimum Eligible Age: 85 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Newcastle University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Tom Kirkwood

Role: PRINCIPAL_INVESTIGATOR

Newcastle University

Locations

Newcastle University

Newcastle upon Tyne, , United Kingdom

Countries

United Kingdom

Other Identifiers

UNewcastle

Identifier Type: -

Identifier Source: org_study_id