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Tea Components, Mental Stress and Blood Pressure

NCT ID: NCT02298530

Last Updated: 2015-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

56 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-03-31

Study Completion Date

2015-11-30

Brief Summary

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Assess the effects of adding theanine to a caffeinated beverage on changes in blood pressure during acute mental stress.

Detailed Description

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Caffeine and (mental) stress can increase blood pressure. In a typical everyday and/or work environment they commonly coincide. Tea has the reputation of being a relaxing drink. L-theanine is an amino acid found almost exclusively in tea. In a previous study it was shown that caffeine increased blood pressure, while theanine antagonised these effects. In the current study the effect of theanine to a placebo on blood pressure are directly compared.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Combination of caffeine and theanine

250 mg caffeine + 200 mg theanine

Group Type EXPERIMENTAL

Combination of caffeine and theanine

Intervention Type OTHER

Beverage containing caffeine and theanine

Caffeine

250 mg caffeine

Group Type PLACEBO_COMPARATOR

Caffeine

Intervention Type OTHER

Beverage containing caffeine

Interventions

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Combination of caffeine and theanine

Beverage containing caffeine and theanine

Intervention Type OTHER

Caffeine

Beverage containing caffeine

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Apparently healthy males and females
* Women taking the contraceptive pill
* 18-45 years of age
* BMI 20-30 kg/m2
* Normal or corrected vision
* Low caffeine consumers (\<100mg/day)
* Non smokers and having been a non-smoker for \> 6 months
* Fluent English
* Normotensive (\>90/60 \<140/90 mmHg)

Exclusion Criteria

* Significant current or medical history of cardiovascular disease
* Low or high STAI trait score in the opinion of the PI
* Known sensitivity to caffeine or theanine
* Colour blindness
* Alcohol consumption above 14/21 units female/male resp. per week
* Weight loss diet \> 10% of bodyweight in the previous year
* Anyone with a dependency on PI or staff of Department of Epidemiology and Public Health or being an employee of Unilever
* Reported participation in another biomedical study \< 3 months before screening
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University College, London

OTHER

Sponsor Role collaborator

Unilever R&D

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Mark Hamer, Dr

Role: PRINCIPAL_INVESTIGATOR

UCL, Epidemiology & Public Health, London

Locations

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University College London

London, , United Kingdom

Site Status

Countries

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United Kingdom

Other Identifiers

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REF-BEV-1803

Identifier Type: -

Identifier Source: org_study_id