Have a Good Grasp of the Worldthe World

NCT ID: NCT02655172

Last Updated: 2019-09-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 41 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-05-24
• Study Completion Date: 2019-04-03

Brief Summary

Brief Summary: In schizophrenia, dislocation of psychic functions involving a loss of contact with reality is frequently found. A fragmentation of motor and sensory perceptions could be held responsible. However, automatic integration between perception and action is the necessary condition to be in "relationship with the world." Affordance is the experimental link between object perception and potentially associated actions (Gibson, 1977, 1979) explored by Stimulus Response Compatibility (SRC) paradigm. With Tucker & Ellis sensory motor compatibility task (1998), with a modified response device (responses given with grasp), we study the impact of motor activation on these affordance effects. In this study, a group of controls will also be included in order to understand, as precisely as possible, the mechanisms involved (i.e., interference between the perception of the object and the response gesture).

Detailed Description

Schizophrenic patients will perform: Alert TEA, (Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield, 1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale, Kay et al., 1987). Controls will only perform the laterality questionnaire. Then all will perform the affordance task, in which photographs of 20 objects of everyday life, typically graspable with one hand, are presented in 4 orientations. Participants have to respond in a graspable device, as quickly as possible, if the object is presented upright or inverted.

Conditions

Schizophrenic Disorders

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Patients

patients suffering schizophrenic disorders and who will perform cognitive tasks + PANSS+ IQ

Group Type: EXPERIMENTAL

cognitive tasks + PANSS+ IQ

Intervention Type: OTHER

Patients will perform different tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield,1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale (Kay et al., 1987) + the experimental task (affordance task with graspable device)

Control group

healthy patients who will perform cognitive tasks

Group Type: ACTIVE_COMPARATOR

cognitive tasks

Intervention Type: OTHER

Healthy volunteers will perform only Edinburgh laterality questionnaire (Oldfield, 1971) + the experimental task (affordance task with graspable device).

Interventions

cognitive tasks + PANSS+ IQ

Patients will perform different tasks: reaction time (Alert TEA, Zimmermann and Fimm, 2005), Edinburgh laterality questionnaire (Oldfield,1971), IQ test (IQ: PM38, Raven, 1960), and the PANSS (Positive and Negative Syndrome Scale (Kay et al., 1987) + the experimental task (affordance task with graspable device)

Intervention Type: OTHER

cognitive tasks

Healthy volunteers will perform only Edinburgh laterality questionnaire (Oldfield, 1971) + the experimental task (affordance task with graspable device).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• For patients:

• a DSM-IV diagnosis of schizophrenia (men or women),
• no change in antipsychotic medication and clinical status within four weeks prior to the study
• For patients and control group • Age ≥ 18 years et ≤ 55 years

Exclusion Criteria

• History of head trauma,
• neurological disease with cerebral repercussion or not stabilized serious physical illness;
• psychotropic medication
• disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

• For patients:

• IQ < 70
• For patients and control group

• History of head trauma,
• neurological disease with cerebral repercussion or not stabilized serious physical illness;
• psychotropic medication
• disorders related to the use of a psychoactive substance (abuse, dependence or withdrawal);

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Centre Hospitalier Universitaire de Saint Etienne

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Anne GROSSELIN, MD

Role: PRINCIPAL_INVESTIGATOR

CHU SAINT-ETIENNE

Locations

Chu Saint-Etienne

Saint-Etienne, , France

Countries

France

Other Identifiers

2015-A01939-40

Identifier Type: OTHER

Identifier Source: secondary_id

1508205

Identifier Type: -

Identifier Source: org_study_id