Study on Communication Comprehension in the Schizophrenic Spectrum

NCT ID: NCT03225027

Last Updated: 2019-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

59 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-15

Study Completion Date

2019-05-27

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of the present study is to evaluate the effect of emotional prosody on the perception of emotional discourse in the schizophrenic spectrum. The investigators hypothesize that participant may use emotional prosody as an emotional cue to understand the emotional content of discourse.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The integration of ortholinguistic and paralinguistic functions in language, particularly of the emotional prosody, is necessary to interact adaptively with others. People in the schizophrenic spectrum have social difficulties. Is emotional prosody comprehension altered in these people? According to Edwards et al. (2002), there is methodological issues concerning the tasks used to answer this question. Investigators built an emotional judgment task more adapted to study the perception of emotional prosody in the schizophrenic spectrum than the classical paradigm designed to evaluate participants with cerebral injury. The investigators have elaborated a material that consists of 140 short sentences (7±2 words) with a simple syntactic structure. The verbal content expressed positive, neutral or negative emotions. These sentences were announced by four professional actors (two female) with an emotional prosody content congruent or inconsistent with the verbal content. Participants will have to evaluate the emotional intensity of the recordings on a five points Likert scale, from strongly negative to strongly positive. Psychotic experiences of all participants will be evaluated too.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Schizophrenia Simple

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

One experimental procedure proposed to three groups of participants
Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with schizophrenia

Emotional judgment task, post-experimental questionnaire, recognition task, detection task, questionnaire CAPE-42, trait emotional intelligence questionnaire and positive and negative syndrome scale.

Group Type EXPERIMENTAL

Emotional judgment task

Intervention Type BEHAVIORAL

Participants had to indicate on a computer the emotional intensity of audio recordings.

Post-experimental questionnaire

Intervention Type BEHAVIORAL

Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.

Recognition task

Intervention Type BEHAVIORAL

Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.

Detection task

Intervention Type BEHAVIORAL

Participants indicate every time they heard a given sound in order to verify their audition level.

CAPE-42

Intervention Type OTHER

This questionnaire allows evaluating the nature of psychotic experiences.

Trait Emotional Intelligence Questionnaire

Intervention Type DIAGNOSTIC_TEST

To evaluate their emotional intelligence.

Positive And Negative Syndrome Scale

Intervention Type DIAGNOSTIC_TEST

Evaluating the clinical status of patients with schizophrenia.

Few psychotic experiences

Healthy participants with few psychotic experience. Participants with the lowest score to the CAPE-42 test. Mini International Neuropsychiatric Interview

Group Type EXPERIMENTAL

Emotional judgment task

Intervention Type BEHAVIORAL

Participants had to indicate on a computer the emotional intensity of audio recordings.

Post-experimental questionnaire

Intervention Type BEHAVIORAL

Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.

Recognition task

Intervention Type BEHAVIORAL

Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.

Detection task

Intervention Type BEHAVIORAL

Participants indicate every time they heard a given sound in order to verify their audition level.

CAPE-42

Intervention Type OTHER

This questionnaire allows evaluating the nature of psychotic experiences.

Trait Emotional Intelligence Questionnaire

Intervention Type DIAGNOSTIC_TEST

To evaluate their emotional intelligence.

Mini International Neuropsychiatric Interview

Intervention Type OTHER

Evaluating the exclusion criteria in healthy participants.

Several psychotic experiences

Healthy participants with several psychotic experiences. Participants with the highest score to the CAPE-42 test. Mini International Neuropsychiatric Interview

Group Type EXPERIMENTAL

Emotional judgment task

Intervention Type BEHAVIORAL

Participants had to indicate on a computer the emotional intensity of audio recordings.

Post-experimental questionnaire

Intervention Type BEHAVIORAL

Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.

Recognition task

Intervention Type BEHAVIORAL

Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.

Detection task

Intervention Type BEHAVIORAL

Participants indicate every time they heard a given sound in order to verify their audition level.

CAPE-42

Intervention Type OTHER

This questionnaire allows evaluating the nature of psychotic experiences.

Trait Emotional Intelligence Questionnaire

Intervention Type DIAGNOSTIC_TEST

To evaluate their emotional intelligence.

Mini International Neuropsychiatric Interview

Intervention Type OTHER

Evaluating the exclusion criteria in healthy participants.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Emotional judgment task

Participants had to indicate on a computer the emotional intensity of audio recordings.

Intervention Type BEHAVIORAL

Post-experimental questionnaire

Participants will be invited to give us the cognitive strategy used to resolve the emotional judgment task.

Intervention Type BEHAVIORAL

Recognition task

Participants will be invited to indicate which recordings they had heard during the emotional judgment task to verify that they have paid attention to the emotional task.

Intervention Type BEHAVIORAL

Detection task

Participants indicate every time they heard a given sound in order to verify their audition level.

Intervention Type BEHAVIORAL

CAPE-42

This questionnaire allows evaluating the nature of psychotic experiences.

Intervention Type OTHER

Trait Emotional Intelligence Questionnaire

To evaluate their emotional intelligence.

Intervention Type DIAGNOSTIC_TEST

Positive And Negative Syndrome Scale

Evaluating the clinical status of patients with schizophrenia.

Intervention Type DIAGNOSTIC_TEST

Mini International Neuropsychiatric Interview

Evaluating the exclusion criteria in healthy participants.

Intervention Type OTHER

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

TEIQUE PANSS MINI

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Having a diagnosis of schizophrenia and being in a stable phase of the disease
* Having between 18 to 60 years old
* Speak french or using french at school
* Accepting not to use psychoactive substances during the preceding 48h
* Being affiliated to the French social security
* Providing their written informed consent


* Having not audio deficits, nor visual uncorrected deficits
* Having not suffering from depressive symptoms during the last 6 months

Exclusion Criteria

\- Having no neurological, nor psychiatric disease except schizophrenia for the patients groups.
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hôpital NOVO

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Mouna TRABELSI, MD

Role: PRINCIPAL_INVESTIGATOR

HDJ François Villon (Centre Hospitaliser René-Dubos)

Virginie BEAUCOUSIN, PhD

Role: STUDY_CHAIR

CRFDP (University of Rouen)

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

HDJ François Villon

Cergy-Pontoise, , France

Site Status

Countries

Review the countries where the study has at least one active or historical site.

France

References

Explore related publications, articles, or registry entries linked to this study.

Brazo P, Beaucousin V, Lecardeur L, Razafimandimby A, Dollfus S. Social cognition in schizophrenic patients: the effect of semantic content and emotional prosody in the comprehension of emotional discourse. Front Psychiatry. 2014 Sep 10;5:120. doi: 10.3389/fpsyt.2014.00120. eCollection 2014.

Reference Type RESULT
PMID: 25309458 (View on PubMed)

Edwards J, Jackson HJ, Pattison PE. Emotion recognition via facial expression and affective prosody in schizophrenia: a methodological review. Clin Psychol Rev. 2002 Jul;22(6):789-832. doi: 10.1016/s0272-7358(02)00130-7.

Reference Type RESULT
PMID: 12214327 (View on PubMed)

Beaucousin V, Lacheret A, Turbelin MR, Morel M, Mazoyer B, Tzourio-Mazoyer N. FMRI study of emotional speech comprehension. Cereb Cortex. 2007 Feb;17(2):339-52. doi: 10.1093/cercor/bhj151. Epub 2006 Mar 8.

Reference Type RESULT
PMID: 16525130 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CHRD0814

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

How Reducing Anxiety in Schizophrenia
NCT02390271 COMPLETED PHASE4