Retrieval Practice and Schizophrenia

NCT ID: NCT02108899

Last Updated: 2022-07-05

Basic Information

• Recruitment Status: SUSPENDED
• Clinical Phase: NA
• Total Enrollment: 50 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-05-31
• Study Completion Date: 2022-12-31

Brief Summary

When people are tested on a previously learned material, they will later remember it better even when compared to a condition where they can re-study it. This phenomenon is called retrieval practice and is supported by an extensive research literature mostly carried out in normal students. This paradigm begins to be used in cognitive remediation programs in patients suffering from memory difficulties.

The objective of this study is to investigate whether retrieval practice is spared in patients with schizophrenia.

If effective, this method could be used in cognitive remediation programs.

Since episodic memory difficulties are supposed to be secondary to deficits in the initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that retrieval practice is spared in schizophrenia.

Conditions

Schizophrenia; Episodic Memory Deficits

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: SUPPORTIVE_CARE
• Blinding Strategy: NONE

Study Groups

Patients with schizophrenia

Group Type: EXPERIMENTAL

Retrieval practice effect using descriptive stories and free-call tests without feedback

Intervention Type: BEHAVIORAL

In the first phase (encoding), people study 2 short prose passages covering general scientific topics.

In the second phase (initial test), they recall one text or restudy the other one.

In the third phase (final test) which takes place 2 days later, they recall both texts.

Healthy subjects

Group Type: ACTIVE_COMPARATOR

Retrieval practice effect using descriptive stories and free-call tests without feedback

Intervention Type: BEHAVIORAL

In the first phase (encoding), people study 2 short prose passages covering general scientific topics.

In the second phase (initial test), they recall one text or restudy the other one.

In the third phase (final test) which takes place 2 days later, they recall both texts.

Interventions

Retrieval practice effect using descriptive stories and free-call tests without feedback

In the first phase (encoding), people study 2 short prose passages covering general scientific topics.

In the second phase (initial test), they recall one text or restudy the other one.

In the third phase (final test) which takes place 2 days later, they recall both texts.

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• French is the native language, or acquired before 5 years old
• People must be able to understand and follow the trial instructions

• Diagnostic of schizophrenia, according to the DSM -5, clinically stable
• The treatment must remain unchanged during the trial

Exclusion Criteria

• Severe or acute cerebral disease
• Other actual psychiatric disorder
• Use of drugs with high anticholinergic effect
• Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)
• Inappropriate use of drugs

• Diagnostic of schizophrenia of a relative up to the third degree

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

University Hospital, Strasbourg, France

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Service de psychiatrie - Hôpital Civil - CHRU Strasbourg

Strasbourg, , France

Countries

France

Other Identifiers

5305

Identifier Type: -

Identifier Source: org_study_id