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Testing Effect and Schizophrenia

NCT ID: NCT02150174

Last Updated: 2025-12-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2015-08-31

Brief Summary

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When people are tested on a previously learned material, they will latter remember it better even when compared to a condition where they can re-study it. This phenomenon is called retrieval practice and is supported by an extensive research literature mostly carried out in normal students. This paradigm begins to be used in cognitive remediation programs in patients suffering from memory difficulties.

The objective of this study is to investigate whether retrieval practice is spared in patients with schizophrenia.

If effective, this method could be used in cognitive remediation programs.

Since episodic memory difficulties are supposed to be secondary to deficits in the initiation/elaboration of efficient encoding and retrieval strategies our hypothesis is that retrieval practice is spared in schizophrenia

Detailed Description

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Conditions

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Schizophrenia Episodic Memory Deficits

Keywords

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Schizophrenia Episodic memory deficits

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Patients with schizophrenia

Group Type EXPERIMENTAL

Retrieval practice effect using word pairs and cued recall tests with feedback

Intervention Type BEHAVIORAL

In the first phase (encoding), people study a list of 48 word pairs non semantically associated.

Then (initial test), they recall half of word pairs or restudy the other half.

In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.

Healthy subjects

Group Type ACTIVE_COMPARATOR

Retrieval practice effect using word pairs and cued recall tests with feedback

Intervention Type BEHAVIORAL

In the first phase (encoding), people study a list of 48 word pairs non semantically associated.

Then (initial test), they recall half of word pairs or restudy the other half.

In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.

Interventions

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Retrieval practice effect using word pairs and cued recall tests with feedback

In the first phase (encoding), people study a list of 48 word pairs non semantically associated.

Then (initial test), they recall half of word pairs or restudy the other half.

In the second phase (final test) which takes place 2 days later, they recall all the 48 the word pairs.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* French is the native language, or acquired before 5 years old
* People must be able to understand and follow the trial instructions


* Diagnostic of schizophrenia, according to the DSM -5, clinically stable
* The treatment must remain unchanged during the trial

Exclusion Criteria

* Severe or acute cerebral disease
* Other actual psychiatric disorder
* Use of drugs with high anticholinergic effect
* Irregular use of benzodiazepines medication, or high dose of benzodiazepin (more than 2 mg of lorazepam per day or equivalent)
* Inappropriate use of drugs


\- Diagnostic of schizophrenia of a relative up to the third degree
Minimum Eligible Age

18 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Strasbourg, France

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Centre Psychothérapique de Nancy

Laxou, , France

Site Status

Service de psychiatrie - Hôpital Civil - CHRU Strasbourg

Strasbourg, , France

Site Status

Countries

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France

References

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Jantzi C, Mengin AC, Serfaty D, Bacon E, Elowe J, Severac F, Meyer N, Berna F, Vidailhet P. Retrieval practice improves memory in patients with schizophrenia: new perspectives for cognitive remediation. BMC Psychiatry. 2019 Nov 11;19(1):355. doi: 10.1186/s12888-019-2341-y.

Reference Type RESULT
PMID: 31711448 (View on PubMed)

Other Identifiers

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5806

Identifier Type: -

Identifier Source: org_study_id