Can we Forget? Directed Forgetting and Embodied Cognition in Schizophrenia

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

96 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-05-31

Study Completion Date

2012-12-31

Brief Summary

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Based on the theory of embodied cognition, which focuses on the influence of sensory and motor processes on cognition, researchers propose to study the influence of the action on memorization and inhibition in patients suffering from schizophrenia, using a directed forgetting paradigm. The directed forgetting paradigm is used, composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

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Detailed Description

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Researchers used the directed forgetting paradigm composed of two lists of action verbs. The instruction "to forget" is given at the end of learning the first list (To Be Forgotten (TBF)), following a simulation of a computer bug. Therefore a second list is presented to be learned and remembered (To Be Remembered (TBR)). A recognition task is performed at the end. The action verbs had to be encoded using four conditions: action performed, mimed, imagined action, action with a contextual word, reading the action verb only. 48 schizophrenic patients were included in this study. Patients were randomized to have 10 participants per condition. 48 controls matched by age, gender, laterality and education are also included and randomized in the same modality. This study aims to show that the encoding of sensory-motor components, more than providing a context could improve the inhibitory capacities but also memory in schizophrenia, and possibly be used in remediation cognitive.

Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

NONE

Simple memorization of the verbs

Group Type ACTIVE_COMPARATOR

Simple memorization of the verbs

Intervention Type OTHER

The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).

Interventions

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Memorization of the verbs by miming the action

The participant reads aloud the verbs that appear on the screen, by performing the corresponding action verb.

Intervention Type OTHER

Memorization of the verbs by imagining the action

The participant reads aloud the verbs that appear on the screen, by imagining the corresponding action verb.

Intervention Type OTHER

Memorization of the action verbs by means of another word

The participant reads aloud the verbs that appear on the screen. Then, he reads, without memorizing it, a word associated with the action verb to be learnt to favor the memorization of that one. The word is written near the action verb.

Intervention Type OTHER

Simple memorization of the verbs

The participant reads aloud the verbs that appear on the screen, without additional instructions (control condition).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Schizophrenic patients as defined in Diagnostic and Statistical Manual of Mental Disorders IV (DSM-IV)
* Stabilized a therapeutic point of view for at least one month.
* Consent form signed
* Affiliated to a Security Health Program

* Consent form signed
* Affiliated to a Security Health Program

Exclusion Criteria

* Not having a history of head trauma, neurological disease or not stabilized serious somatic illness,
* Not to use psychoactive substance, as defined by the DSM IV.
* The Intelligence Quotient must not be less than 70 (Progressive Matrices Standard score (PM38), Raven Progressive Matrix).

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes