Influence of Meal Skipping on Macronutrient Oxidation and Glucose Metabolism Under Isocaloric Conditions

NCT ID: NCT02635139

Last Updated: 2017-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-12-31

Study Completion Date

2016-10-31

Brief Summary

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Aim of the study is to investigate the impact of meal skipping (breakfast or dinner skipping) on the regulation of glucose metabolism and macronutrient balance (protein/fat/carbohydrate intake vs. -oxidation). An isoenergetic diet with 3 conventional meals (breakfast, lunch, dinner) serves as a control.

Detailed Description

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The duration of the study is 7 days including 3 days with controlled diet and 4 days (including 5 nights) in a metabolic chamber at the Institute of Nutritional Medicine at the University of Hohenheim.

The study phase in the metabolic chamber consists of (i) 1 day with 3 meals/day = baseline day, (ii) 1 day with breakfast skipping, (iii) 1 day with dinner skipping, (iv) 1 washout day where the subjects leave the chamber between 7 a.m. until 7 p.m..

Beginning on the 3rd study day macronutrient and energy intake as well as the fasting periods are kept constant. To achieve comparable conditions the washout day is setted before the baseline day.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Breakfast Skipping

Effect of breakfast skipping on metabolism

Group Type EXPERIMENTAL

Breakfast skipping

Intervention Type BEHAVIORAL

18h fasting period in the morning

Dinner Skipping

Effect of dinner skipping on metabolism

Group Type EXPERIMENTAL

Dinner skipping

Intervention Type BEHAVIORAL

18h fasting period in the evening

Interventions

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Breakfast skipping

18h fasting period in the morning

Intervention Type BEHAVIORAL

Dinner skipping

18h fasting period in the evening

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* healthy
* not obese (BMI\<30)

Exclusion Criteria

* food allergy
* smoking
* alternative nutrition habits
* chronic disease
* regular medication intake
* claustrophobia
Minimum Eligible Age

20 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Hohenheim

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Anja Bosy-Westphal, Prof PhD

Role: PRINCIPAL_INVESTIGATOR

University of Hohenheim, Stuttgart, Germany

Locations

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Institute of Nutritional Medicine, University of Hohenheim

Stuttgart, , Germany

Site Status

Countries

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Germany

References

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Nas A, Mirza N, Hagele F, Kahlhofer J, Keller J, Rising R, Kufer TA, Bosy-Westphal A. Impact of breakfast skipping compared with dinner skipping on regulation of energy balance and metabolic risk. Am J Clin Nutr. 2017 Jun;105(6):1351-1361. doi: 10.3945/ajcn.116.151332. Epub 2017 May 10.

Reference Type DERIVED
PMID: 28490511 (View on PubMed)

Other Identifiers

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MealSkipping

Identifier Type: -

Identifier Source: org_study_id

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