Effect of Skipping Breakfast on Metabolic Function

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-05-31

Study Completion Date

2017-05-05

Brief Summary

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The purpose of this study is to test the hypothesis that the disruption of the "normal" (three meals a day) eating pattern and prolonged overnight fasting caused by skipping breakfast: i) alters the expression of specific clock genes and clock gene targets involved in regulating adipose tissue lipolysis (breakdown or destruction); ii) increases basal adipose tissue lipolytic (breakdown) activity and plasma free fatty acid (FFA) concentrations; iii) reduces skeletal muscle insulin sensitivity; and iv) increases daylong plasma glucose, FFA, and insulin concentrations. The investigator will do this by studying healthy, lean persons either randomized to consume either 3 standard meals per day or omit breakfast and consume 2 meals per day without changing daily calorie intake (skipping breakfast group).

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Detailed Description

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Conditions

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Skipping Breakfast Circadian Rhythms

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Control

Subjects randomized to this group will consume 3 standard meals/day during the 2 week intervention period of the study.

Group Type EXPERIMENTAL

3 standard meals/day

Intervention Type OTHER

Breakfast skipping

Subjects randomized to this group will consume 2 meals/day (omit breakfast - with caloric intake equal to consuming 3 meals/day) during the 2 week intervention period of the study.

Group Type EXPERIMENTAL

2 meals/day (omit breakfast)

Intervention Type OTHER

Interventions

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3 standard meals/day

Intervention Type OTHER

2 meals/day (omit breakfast)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Males \& females
* 18-55 years old
* BMI between 18.5 - 29.9 kg/m²
* Sleeps \>7 hours/night
* Normally consume 3 meals/day, including breakfast

Exclusion Criteria

* Pregnancy, lactating or breastfeeding
* Diabetes
* Sleep disorders
* Significant organ dysfunction
* Shift or nighttime workers
* Smokers
* Breakfast skippers
* People who regularly sleep \<7 hours/night
* Consume excess amounts of alcohol
* Medications that could alter the results of this study

Minimum Eligible Age

18 Years

Maximum Eligible Age

55 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes