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Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults

Last Updated: 2019-02-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-05-12

Study Completion Date

2022-05-31

Brief Summary

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The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.

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Detailed Description

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During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear.

The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups.

The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.

Conditions

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Coronary Artery Disease Percutaneous Coronary Intervention

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Early-onset CAD

The anticipated 2000 young CAD patients who aged ≤45years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

No interventions assigned to this group

Late-onset CAD

The anticipated 2000 old CAD patients aged≥65years undergoing coronary angiography will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

No interventions assigned to this group

Age-matched controls

The anticipated 2000 control subjects without obvious coronary stenosis aged≤45years or ≥65years will be recruited in the prospective cohort. Medical history and risk-factor information were obtained by interviewing patients and by abstracting information from medical records.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

1. premature CAD, includes patients who aged ≥ 18 and ≤ 45 years , and with at least one main coronary artery stenosis ≥ 50% confirmed by coronary angiography, involving left main coronary artery, left anterior descending branch, left circumflex branch or right coronary artery, and manifested as occult CAD, stable CAD, unstable angina pectoris, non-ST segment elevated myocardial infarction and ST segment elevated myocardial infarction;
2. mature CAD, refers to patients who aged ≥ 65 years and meat the same CAD diagnostic criteria as above;
3. age matched individuals who had coronary arteries without obvious stenosis.

Exclusion Criteria

1. severely sick with limited life-expectancy \< 1 year;
2. patients with malignancies;
3. pregnant or planning for pregnancy.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Responsible Party

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Junbo Ge

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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China-Japan Friendship Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

Xiamen Cardiovascular Hospital

Xiamen, Fujian, China

Site Status RECRUITING

The First Hospital of Lanzhou University

Lanzhou, Gansu, China

Site Status RECRUITING

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Sun yat-sen Memorial Hospital

Guangzhou, Guangdong, China

Site Status RECRUITING

Zhuhai Hospital of Guangdong Provincial People's Hospital

Zhuhai, Guangdong, China

Site Status RECRUITING

The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine

Nanning, Guangxi, China

Site Status RECRUITING

Affiliated Hospital of Zunyi Medical College

Zunyi, Guizhou, China

Site Status RECRUITING

The second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

Site Status RECRUITING

Wuhan Asia Heart Hospital

Wuhan, Hubei, China

Site Status RECRUITING

Wuxi Third People's Hospital

Wuxi, Jiangsu, China

Site Status RECRUITING

Xuzhou Fourth People's Hospital

Xuzhou, Jiangsu, China

Site Status RECRUITING

The First Affiliated Hospital of Nanchang University

Nanchang, Jiangxi, China

Site Status RECRUITING

The second Hospital of Jilin University

Changchun, Jilin, China

Site Status RECRUITING

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

Site Status RECRUITING