Understanding the Genetic Basis of Atherosclerosis and Peripheral Arterial Disease

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

1789 participants

Study Classification

OBSERVATIONAL

Study Start Date

2004-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Atherosclerosis, a condition in which fatty deposits build up along the inner walls of arteries, can occur throughout the body. The purpose of this study is to examine the possible genetic differences that may influence where atherosclerosis occurs.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Understanding the Genetic and Hereditary Basis of Atherosclerosis

NCT00344292

Atherosclerosis Cardiovascular Diseases

COMPLETED

Genetic Factors in Atherosclerosis

NCT00359307

Atherosclerosis

COMPLETED

Identification of Genes Expressed in Atherosclerotic Plaque

NCT00353730

Atherosclerosis

COMPLETED

Epidemiology of Atherosclerosis

NCT00005147

Atherosclerosis Cardiovascular Diseases Heart Diseases +1 more

COMPLETED

Genetics of Peripheral Artery Genomics

NCT00615121

Peripheral Artery Disease

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Plaque build-up caused by atherosclerosis increases the risk of blood clots, heart attack, and stroke. Blockages of plaque can occur in different areas of the body. PAD, a circulatory disorder in which blockages occur in the peripheral arteries, is one manifestation of atherosclerosis. Individuals with PAD experience reduced blood flow to the legs, which may cause leg pain while walking. Coronary artery disease (CAD), in which plaque builds up in arteries leading to the heart, is another atherosclerosis-related condition. Individuals with PAD and CAD have similar atherosclerosis risk factors, but it remains unknown why some individuals develop one disease and not the other. Genetic differences may influence where atherosclerosis develops. The goal of the study is to identify genetic variations that may cause inherited differences in plaque distribution.

This study will enroll individuals with PAD who have been referred by their doctor for a coronary angiogram to confirm the presence of CAD. A control group composed of individuals who do not have PAD, but have similar risk factors for atherosclerosis, will also be enrolled. All participants will attend one study visit. They will undergo a coronary angiogram, a procedure in which a special dye is inserted intravenously into an artery of the heart. X-rays will be taken to document how blood flows through the artery. Questionnaires assessing quality of life, exercise habits, tobacco exposure, and family medical history will be completed. Participants will also undergo blood pressure measurements and blood collection for genetic analysis. Yearly follow-up phone calls will occur for 5 years to document any hospitalizations.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Peripheral Vascular Diseases

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

1

Subjects with no hemodynamically significant disease (NHSD) of the coronary or peripheral arteries

No interventions assigned to this group

2

Subjects with coronary artery disease only

No interventions assigned to this group

3

Subjects with both coronary artery disease and peripheral arterial disease

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Hemodynamically significant PAD, as documented by an ankle-brachial index less than 0.9; control group participants will not have PAD
* Received a referral for an elective coronary angiogram
* Suspected CAD