Genetic of Aortic Valve Stenosis - Clinical and Therapeutic Implications

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

2200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-03-31

Study Completion Date

2017-12-31

Brief Summary

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Pathophysiology of Aortic Valve Stenosis remains poorly known. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design.

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Detailed Description

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Aortic valve stenosis (AS) is the most common valvular disease and the second most common indication for cardiac surgery in Western countries. AS has long been considered as a passive and degenerative process. Recent data challenged this concept, showing that AS is an active and highly regulated process with some similarities to atherosclerosis. However, pathophysiology of AS remains poorly understood and preliminary data suggest that genetic factors may be involved. The aim of the present study is to identify genetic factors involved in this disease using a case control trial design (1000 patients with AS and 1500 controls with no evidence of valve disease). For all patients and controls, blood samples including DNA and echocardiography will be performed.

Conditions

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Aortic Valve Stenosis

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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aortic stenosis

various age and disease severity

No interventions assigned to this group

Controls

Controls free of valvular disease

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age \>=18 years
* Pure isolated degenerative aortic valve stenosis

\- Age \>=18 years

Exclusion Criteria

* Rheumatic, congenital or post-radiation aortic stenosis
* Severe renal insufficiency (clearance \< 30 ml/min)
* Aortic insufficiency \> or = grade 2/4
* Other valve disease \> or = grade 2/4

Controls

* Known first degree relative with aortic valve stenosis
* Severe renal insufficiency (clearance \< 30 ml/min)
* Any valve disease \> or = grade 2/4

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes