Study on Susceptibility Genes and Pathogenic Mechanism of Non-syndromic Familial Aortic Dissection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-17

Study Completion Date

2023-07-17

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Aortic dissection is dangerous and difficult to predict, so it is particularly important to carry out early prevention, diagnosis and rational treatment for high-risk groups. The related genes found in previous studies can not be detected in all patients with dissection; at present, the pathogenesis of non-syndromic aortic dissection is not clear, of which about 20% of patients have family aggregation and have the general representative characteristics of non-syndromic dissection. In this project, the peripheral blood samples of core family subjects were detected by sequencing technique. analyze disease-related susceptibility genes; 2 determine the effect of susceptibility genes on the incidence of dissection in mice through animal experiments; and 3 explore the effect of susceptibility genes on cell function at the cellular level.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection

NCT02852603

Dissection of Aorta, Thoracic Aneurysm of Aorta, Thoracic

COMPLETED

Aortic Dilatation Under 5 cm: Genetic Risk Mapping

NCT07034430

Ascending Aortic Dilatation Aortic Aneurysm, Thoracic Aortic Diseases

ACTIVE_NOT_RECRUITING

Clinical and Genetic Characteristics of Coronary Artery Disease in Chinese Young Adults

NCT02496858

Coronary Artery Disease Percutaneous Coronary Intervention

UNKNOWN

Genetics of Aortic Stenosis: From Family Forms to the Common Forms

NCT02890407

Aortic Stenosis

COMPLETED

Genetic Profile in Patients With Aortic Syndrome

NCT04751058

Gene Abnormality Acute Aortic Syndrome

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aortic Dissection Family Research Aortic Dissection, Familial, With or Without Aortic Aneurysm

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

FAMILY_BASED

Study Time Perspective

OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

movement

aortic dissection or aneurysm patients this is an observation cohort study about a Non-syndromic Familial Aortic Dissection without intervention.

Intervention Type GENETIC

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Inclusion Criteria:

* Family inclusion criteria: 1 at least one person in each generation of a family has aortic dissection, and at least two generations of members can be included;

Exclusion Criteria:

* Pedigree exclusion criteria: pedigree members have marfan syndrome, Loeys-Dietz syndrome, Ehler-Danlos syndrome, aneurysm-Osteoarthritis syndrome and other syndroms

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes