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Study on Genetically Affected Sporadic Thoracic Aortic Aneurysm and Dissection

NCT ID: NCT02852603

Last Updated: 2021-04-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

450 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-08-31

Study Completion Date

2020-01-31

Brief Summary

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Mortality of thoracic aortic aneurysm and dissection (TAAD) remains high because of the huge blood lost from the aorta. Questions about the potentially genetic effects on sporadic TAAD are raised by researchers to explore the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

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Detailed Description

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Thoracic aortic dissection (TAD) is a critical clinical condition partly due to the rupture of aortic aneurysm. Mostly, surgical treatment can reduce the symptoms and extend life span of patients with thoracic aortic aneurysm and dissection (TAAD). However, mortality of TAAD remains high because of the huge blood lost from the aorta. Sporadic TAAD was considered to be a server consequence of hypertension, though most patients with hypertension won't have TAAD as their final outcomes. Previous studies have revealed the associations between genetic abnormalities and familial TAAD, and genetic tests have applied to assist the diagnosis of certain TAAD. Therefore, the potentially genetic effects on sporadic TAAD are explored by researchers to understand the possible mechanisms leading to sporadic TAAD and to establish new clinical approaches to prevent TAAD-caused adverse clinical outcomes. This study is intended to collect the gene information in sporadic TAAD patients and to explore the relationship between genetic variation and the incidence of sporadic TAAD for further study.

Conditions

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Dissection of Aorta, Thoracic Aneurysm of Aorta, Thoracic

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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thoracic aortic aneurysm and dissection

Patients with thoracic aortic aneurysm and/or dissection are recruited in the study.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with thoracic aortic aneurysm and dissection not due to trauma

Exclusion Criteria

* Inability of the patient, parent or guardian to give consent
* Unwillingness to provide a blood specimen or participate in the study
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Fu Wai Hospital, Beijing, China

OTHER

Sponsor Role collaborator

Wuhan Asia Heart Hospital

OTHER

Sponsor Role lead

Responsible Party

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Xuan Zheng

vice director of laboratory of molecular cardiology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Xuan Zheng, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Wuhan Asia Heart Hospital

Locations

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Wuhan Asia Heart Hospital

Wuhan, Hubei, China

Site Status

Countries

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China

Other Identifiers

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2016LMC-2

Identifier Type: -

Identifier Source: org_study_id

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