Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study

NCT ID: NCT00262691

Last Updated: 2007-09-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

7000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-05-31

Brief Summary

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Cardiovascular disease is a complex multifactorial and polygenic disorder that is thought to result from an interaction between a person's genetic make up and various environmental factors. Although many studies have revealed that several genetic variants increase the risk of cardiovascular disease, the results of these studies remain controversial. The purpose of this study is to identify polymorphisms that confer susceptibility to cardiovascular disease and to clarify the adequacy of reported susceptibility gene polymorphisms. To complete this purpose, we will prospectively study over 5,000 local residents in whom relationship between these polymorphisms and occurrence of cardiovascular disease over 5 years.

Detailed Description

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Conditions

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Healthy Coronary Disease Myocardial Infarction Cerebral Infarction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects who undergo community-based annual health check in Kitanagoya city
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Aichi Gakuin University

OTHER

Sponsor Role collaborator

Nagoya University

OTHER

Sponsor Role lead

Principal Investigators

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Mitsuhiro Yokota, MD, PhD

Role: STUDY_CHAIR

Department of Genome Science, School o Dentistry, Aichi-Gakuin University

Locations

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Department of Genome Science, School of Dentistry, Aichi-Gakuin University

Nagoya, Aichi-ken, Japan

Site Status RECRUITING

Countries

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Japan

Central Contacts

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Mitsuhiro Yokota, MD, PhD

Role: CONTACT

Phone: +81-52-759-2111

Email: [email protected]

Mitsuhiro Yokota, MD, PhD

Role: CONTACT

Phone: +81-52-744-5515

Email: [email protected]

Facility Contacts

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Mitsuhiro Yokota, MD, PhD

Role: primary

References

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Nakatochi M, Ichihara S, Yamamoto K, Naruse K, Yokota S, Asano H, Matsubara T, Yokota M. Epigenome-wide association of myocardial infarction with DNA methylation sites at loci related to cardiovascular disease. Clin Epigenetics. 2017 May 15;9:54. doi: 10.1186/s13148-017-0353-3. eCollection 2017.

Reference Type DERIVED
PMID: 28515798 (View on PubMed)

Nakatochi M, Miyata S, Tanimura D, Izawa H, Asano H, Murase Y, Kato R, Ichihara S, Naruse K, Matsubara T, Honda H, Yokota M. The ratio of adiponectin to homeostasis model assessment of insulin resistance is a powerful index of each component of metabolic syndrome in an aged Japanese population: results from the KING Study. Diabetes Res Clin Pract. 2011 Jun;92(3):e61-5. doi: 10.1016/j.diabres.2011.02.029. Epub 2011 Mar 31.

Reference Type DERIVED
PMID: 21458098 (View on PubMed)

Tanimura D, Shibata R, Izawa H, Hirashiki A, Asano H, Murase Y, Miyata S, Nakatochi M, Ouchi N, Ichihara S, Yasui K, Yoshida T, Naruse K, Matsubara T, Yokota M. Relation of a common variant of the adiponectin gene to serum adiponectin concentration and metabolic traits in an aged Japanese population. Eur J Hum Genet. 2011 Mar;19(3):262-9. doi: 10.1038/ejhg.2010.201. Epub 2010 Dec 8.

Reference Type DERIVED
PMID: 21150884 (View on PubMed)

Asano H, Izawa H, Nagata K, Nakatochi M, Kobayashi M, Hirashiki A, Shintani S, Nishizawa T, Tanimura D, Naruse K, Matsubara T, Murohara T, Yokota M. Plasma resistin concentration determined by common variants in the resistin gene and associated with metabolic traits in an aged Japanese population. Diabetologia. 2010 Feb;53(2):234-46. doi: 10.1007/s00125-009-1517-2. Epub 2009 Sep 1.

Reference Type DERIVED
PMID: 19727657 (View on PubMed)

Other Identifiers

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NU-05-G-0001

Identifier Type: -

Identifier Source: org_study_id