Effect of Induction and Maintenance of Anesthesia With Etomidate on Hemodynamics and Oxidative Stress in Diabetic Patients
NCT ID: NCT02202239
Last Updated: 2014-07-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
60 participants
INTERVENTIONAL
2014-09-30
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Group E
Etomidate was used in both induction and maintenance of anesthesia.
midazolam
Before induction, midazolam 0.05mg/kg will be injected intravenously.
Penehyclidine Hydrochloride Injection
Penehyclidine Hydrochloride 0.01mg/kg will be injected intravenously after midazolam is injected.
Etomidate
Induction dose: 0.3 mg/kg. Maintenance dose: 10 μg•kg-1•min-1.
Fentanyl
During induction, after injection of etomidate, fentanyl 3 μg/kg will be given intravenously.
Cisatracurium Besilate
Cisatracurium Besilate 0.14 mg/kg will be used after fentanyl is injected for induction.
During maintenance, intermittent bolus of cisatracurium will be used for maintain muscle relaxation.
Remifentanil
Remifentanil will be injected continuously during maintenance of anesthesia.
Sevoflurane
Sevoflurane of 1% to 2% will be administered via inhalation to keep bispectral index（BIS) between 50 to 55.
Group P
Propofol was used in both induction and maintenance of anesthesia.
midazolam
Before induction, midazolam 0.05mg/kg will be injected intravenously.
Propofol
Induction dose: 2.0 mg/kg. Maintenance dose: 4 to 6 mg/kg/h.
Fentanyl
During induction, after injection of etomidate, fentanyl 3 μg/kg will be given intravenously.
Cisatracurium Besilate
Cisatracurium Besilate 0.14 mg/kg will be used after fentanyl is injected for induction.
During maintenance, intermittent bolus of cisatracurium will be used for maintain muscle relaxation.
Remifentanil
Remifentanil will be injected continuously during maintenance of anesthesia.
Sevoflurane
Sevoflurane of 1% to 2% will be administered via inhalation to keep bispectral index（BIS) between 50 to 55.
Interventions
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midazolam
Before induction, midazolam 0.05mg/kg will be injected intravenously.
Penehyclidine Hydrochloride Injection
Penehyclidine Hydrochloride 0.01mg/kg will be injected intravenously after midazolam is injected.
Etomidate
Induction dose: 0.3 mg/kg. Maintenance dose: 10 μg•kg-1•min-1.
Propofol
Induction dose: 2.0 mg/kg. Maintenance dose: 4 to 6 mg/kg/h.
Fentanyl
During induction, after injection of etomidate, fentanyl 3 μg/kg will be given intravenously.
Cisatracurium Besilate
Cisatracurium Besilate 0.14 mg/kg will be used after fentanyl is injected for induction.
During maintenance, intermittent bolus of cisatracurium will be used for maintain muscle relaxation.
Remifentanil
Remifentanil will be injected continuously during maintenance of anesthesia.
Sevoflurane
Sevoflurane of 1% to 2% will be administered via inhalation to keep bispectral index（BIS) between 50 to 55.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Diabetic patients preparing for elective surgery;
* Body mass index is between 16 and 30 kg/m2;
* Blood glucose is under 8.3 mmol/kg by oral antidiabetic agents or diet control;
* American Society of Anesthesiology (ASA) Physical Status: Ⅰ or Ⅱ;
* Expected operation duration is between 2 and 8 h;
* Signed informed consent form.
Exclusion Criteria
* Chemotherapy or immunotherapy before the surgery;
* Allergy to trial drug or other contraindication;
* Expected or history of difficult airway;
* Suspected abuse of narcotic analgesia;
* Diseases of neuromuscular system;
* Mentally unstable or has a mental illness;
* Trend of malignant hyperthermia;
* Pregnant or breast-feeding women;
* Attendance of other trial past 30 days.
18 Years
65 Years
ALL
No
Sponsors
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Zhujiang Hospital
OTHER
Responsible Party
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Other Identifiers
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20140723
Identifier Type: -
Identifier Source: org_study_id
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