Dexmedetomidine Influence on the Level of Perioperative Blood Glucose and Insulin of Elderly Diabetes Patients
NCT ID: NCT02154074
Last Updated: 2014-06-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE4
92 participants
INTERVENTIONAL
2014-05-31
2014-10-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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N1 group: Isoflurane & saline
for normal patients: inhale Isoflurane + the same volume of saline during operation
general anesthesia induction
general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg
Isoflurane
inhale Isoflurane 1.5MAC
normal saline
the same volume of saline + Isoflurane during operation
N2 group: Isoflurane & Dexmedetomidine
for normal patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
general anesthesia induction
general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg
Isoflurane
inhale Isoflurane 1.5MAC
Dexmedetomidine
anesthesia induction period: intravenous pumping Dexmedetomidine 4ug/Kg/h; after 10 minutes,turn to 0.4ug/Kg/h.
D1 group: Isoflurane & saline
for diabetes patients: inhale Isoflurane + the same volume of saline during operation
general anesthesia induction
general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg
Isoflurane
inhale Isoflurane 1.5MAC
normal saline
the same volume of saline + Isoflurane during operation
D2 group: Isoflurane & Dexmedetomidi
for diabetes patients: inhale Isoflurane + intravenous pumping Dexmedetomidine during operation
general anesthesia induction
general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg
Isoflurane
inhale Isoflurane 1.5MAC
Dexmedetomidine
anesthesia induction period: intravenous pumping Dexmedetomidine 4ug/Kg/h; after 10 minutes,turn to 0.4ug/Kg/h.
Interventions
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general anesthesia induction
general anesthesia induction: midazolam 0.1mg/Kg, sufentanil 1ug/Kg, cisatracurium 0.15mg/Kg, and then immediatly administrate etomidate 0.2 mg/Kg
Isoflurane
inhale Isoflurane 1.5MAC
Dexmedetomidine
anesthesia induction period: intravenous pumping Dexmedetomidine 4ug/Kg/h; after 10 minutes,turn to 0.4ug/Kg/h.
normal saline
the same volume of saline + Isoflurane during operation
Eligibility Criteria
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Inclusion Criteria
* Type 2 diabetes;
* Not use insulin treatment;
* Onging general anesthesia surgery;
* Surgery time 1-3 hours
Exclusion Criteria
* Hypertension;
* Serious central nervous system diseases (acute stroke, uncontrolled seizures, -Severe dementia);
* Unstable angina and acute myocardial infarction;
* Allergy to investigational drug;
* Hepatic and renal dysfunction
60 Years
80 Years
ALL
No
Sponsors
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Second Affiliated Hospital of Xi'an Jiaotong University
OTHER
Responsible Party
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Locations
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SecondXianJiaotongU
Xi’an, Shanxi, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Dexmedetomidine 20140527
Identifier Type: -
Identifier Source: org_study_id
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