Effects of Dexmedetomidine on Cardiac Electrophysiology in Patients Under General Anesthesia During Perioperative Period
NCT ID: NCT04577430
Last Updated: 2021-08-31
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
81 participants
INTERVENTIONAL
2019-09-08
2021-03-16
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
TRIPLE
Study Groups
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Loading dose with 0.5 μg/kg, maintenance dose with 0.5 μg/kg
10 min before induction of anesthesia,the loading dose of dexmedetomidine is 0.5 μg/kg, and completed in 10 minutes. The maintenance dose is 0.5 μg/kg per hour during the operation until 0.5 h before the operation finished.
Dexmedetomidine
The loading dose with 0.5 μg/kg, maintenance dose with 0.5 μg/kg of Dexmedetomidine is used to observe the effect on the electrophysiology of the patients' hearts
Loading dose with 1 μg/kg, maintenance dose with 0.5 μg/kg
10 min before induction of anesthesia,the loading dose of dexmedetomidine is 1 μg/kg, and completed in 10 minutes. The maintenance dose is 0.5 μg/kg per hour during the operation until 0.5 h before the surgery finished.
Dexmedetomidine
The loading dose with 1 μg/kg, maintenance dose with 0.5 μg/kg of Dexmedetomidine is used to observe the effect on the electrophysiology of the patients' hearts
Loading dose with 1 μg/kg, maintenance dose with 1 μg/kg
10 min before induction of anesthesia,the loading dose of dexmedetomidine is 1 μg/kg, and completed in 10 minutes. The maintenance dose is 1 μg/kg per hour during the operation until 0.5 h before the surgery finished.
Dexmedetomidine
The loading dose with 1 μg/kg, maintenance dose with 1 μg/kg of Dexmedetomidine is used to observe the effect on the electrophysiology of the patients' hearts
Normal saline
Normal saline
Normal saline is used to observe the effect on the electrophysiology of the patients' hearts
Interventions
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Dexmedetomidine
The loading dose with 0.5 μg/kg, maintenance dose with 0.5 μg/kg of Dexmedetomidine is used to observe the effect on the electrophysiology of the patients' hearts
Dexmedetomidine
The loading dose with 1 μg/kg, maintenance dose with 0.5 μg/kg of Dexmedetomidine is used to observe the effect on the electrophysiology of the patients' hearts
Dexmedetomidine
The loading dose with 1 μg/kg, maintenance dose with 1 μg/kg of Dexmedetomidine is used to observe the effect on the electrophysiology of the patients' hearts
Normal saline
Normal saline is used to observe the effect on the electrophysiology of the patients' hearts
Eligibility Criteria
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Inclusion Criteria
* ASA I\~II
* patients undergoing elective general anesthesia
* the surgery time for 1\~3 h
Exclusion Criteria
* abnormal cardiac conduction, prolonged QT syndrome
* heart disease history, such as pacemaker implantation, unstable angina, congestive heart failure, Heart valve disease
* antiarrhythmic drugs (β-receptor blockers, calcium channel blockers, tricyclic antidepressants, etc.) that can prolong the QT interval taken within one week before surgery
* coronary heart disease, non-sinus Heart rhythm, bradycardia, tachycardia, other arrhythmia, etc
* intraoperative HR≤45 beats/min and need drugs to increase heart rate
* previous allergy to dexmedetomidine
* preoperative electrolyte abnormalities
* emergency surgery, neurological or mental disorders , Liver and kidney dysfunction
* patients who use analgesic pumps after surgery
* refusal of patients
18 Years
65 Years
ALL
Yes
Sponsors
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Yangzhou University
OTHER
Responsible Party
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Zhuan Zhang
Principal Investigator
Locations
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the Affiliated Hospital of Yangzhou University, Yangzhou University
Yangzhou, Jiangsu, China
Countries
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References
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Tan C, Yan S, Shen J, Wu H, Yu L, Wang Y, Tian S, Zhou W, Wu Y, Zhang Z. Effects of dexmedetomidine on cardiac electrophysiology in patients undergoing general anesthesia during perioperative period: a randomized controlled trial. BMC Anesthesiol. 2022 Aug 25;22(1):271. doi: 10.1186/s12871-022-01811-5.
Other Identifiers
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20200915
Identifier Type: -
Identifier Source: org_study_id
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