Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus
NCT ID: NCT01963546
Last Updated: 2014-09-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
80 participants
INTERVENTIONAL
2014-03-31
2015-10-31
Brief Summary
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Detailed Description
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1. Preparation of serum: 3ml of blood were taken before induction of anesthesia (after entering the operating room), surgery began 1h, surgery began 2h, 24h after surgery, and placed at dry tube, centrifuged for 10min at 3000g after placing at room temperature for 2h , the resulting supernatant was subpassaged in tube, stored at -20℃ until analysis.
2. Indicators to detect in serum contained Tumor Necrosis Factor-α, Interleukin-6, Interleukin-10, plasma glucose, cortisol,insulin and c-peptide.
3. Record the vital signs.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
NONE
Study Groups
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Intravenous anesthesia
We use total intravenous anesthesia to assess the stress response.
different types of anesthesia
Intravenous and Inhalation anesthesia
We use intravenous and inhalation anesthesia during the surgery.
different types of anesthesia
Inhalation anesthesia
We use inhalation anesthesia during the surgery.
different types of anesthesia
Dexmedetomidine
the effect of dexmedetomidine on the stress responses generated by patients with diabetic given gastric-bypass surgery : Group A group given the best anesthetic technique from preliminary work + dexmedetomidine Dexmedetomidine as a inducer was given intravenous infusion loading dose 1.0μg/kg for 10min, maintained intravenous infusion by 0.4μg/kg/h.
Group B group given the best anesthesia method from preliminary work(not using dexmedetomidine).
Dexmedetomidine
After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.The stress indicators are the same as described above.
Interventions
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different types of anesthesia
Dexmedetomidine
After selecting the appropriate anesthesia method, assess the effect of dexmedetomidine on controlling stress response from diabetics undergoing laparoscopic gastric-bypass surgical.The stress indicators are the same as described above.
Eligibility Criteria
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Inclusion Criteria
* Type 2 Diabetes Mellitus patient undergoing Laparoscopic Gastric Bypass surgery
* between 18 and 60 years of age
Exclusion Criteria
* Thyroid disease
18 Years
60 Years
ALL
No
Sponsors
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Guangzhou General Hospital of Guangzhou Military Command
OTHER
Responsible Party
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Wenbin Qie
Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus
Principal Investigators
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Tu wei feng, Postdoctoral
Role: PRINCIPAL_INVESTIGATOR
The General Hospital Of Guangzhou Military Command
Locations
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The General Hospital Of Guangzhou Military Command
Guangzhou, Guangdong, China
Countries
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Central Contacts
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Facility Contacts
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References
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Cheng YC, Cheng XB, Li XJ, Wang FZ, Li ZK. Combined general and regional anesthesia and effects on immune function in patients with benign ovarian tumors treated by laparoscopic therapy. Int J Clin Exp Med. 2013 Sep 1;6(8):716-9. eCollection 2013.
Dell'Aquila AM, Ellger B. Perioperative glycemic control: what is worth the effort? Curr Opin Anaesthesiol. 2013 Aug;26(4):438-43. doi: 10.1097/ACO.0b013e328362d16a.
Ezhevskaya AA, Mlyavykh SG, Anderson DG. Effects of continuous epidural anesthesia and postoperative epidural analgesia on pain management and stress response in patients undergoing major spinal surgery. Spine (Phila Pa 1976). 2013 Jul 1;38(15):1324-30. doi: 10.1097/BRS.0b013e318290ff26.
Hadimioglu N, Ulugol H, Akbas H, Coskunfirat N, Ertug Z, Dinckan A. Combination of epidural anesthesia and general anesthesia attenuates stress response to renal transplantation surgery. Transplant Proc. 2012 Dec;44(10):2949-54. doi: 10.1016/j.transproceed.2012.08.004.
Other Identifiers
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WQie
Identifier Type: -
Identifier Source: org_study_id
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