The Effects of Intraoperative Dexmedetomidine Infusion on Postoperative Bowel Movement in Patients Undergoing Laparoscopic Gastrectomy

NCT ID: NCT02164448

Last Updated: 2015-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

92 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2015-01-31

Brief Summary

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The investigators hypothesized that sympatholytic effect of dexmedetomidine would attenuate the hemodynamic instability and decrease in the splanchnic blood flow caused by pneumoperitoneum during laparoscopic surgery. This study is to investigate the effect of intraoperative dexmedetomidine infusion on postoperative bowel movement in patients undergoing laparoscopic gastrectomy.

Detailed Description

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Conditions

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Gastric Cancer Patients Undergoing Laparoscopic Gastrectomy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

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dexmedetomidine group

Group Type EXPERIMENTAL

the dexmedetomidine group

Intervention Type DRUG

the dexmedetomidine group: dexmedetomidine infusion from induction of anesthesia to end of surgery

control group

Group Type PLACEBO_COMPARATOR

the control group

Intervention Type DRUG

saline infusion from induction of anesthesia to end of surgery

Interventions

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the dexmedetomidine group

the dexmedetomidine group: dexmedetomidine infusion from induction of anesthesia to end of surgery

Intervention Type DRUG

the control group

saline infusion from induction of anesthesia to end of surgery

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* patient between 20 and 65 of age with ASA physical status Ⅰ-Ⅲ
* gastric cancer patient undergoing laparoscopic gastrectomy

Exclusion Criteria

* ASA physical status Ⅳ
* bradycardia (\< 60 bpm), arrhythmia
* uncompensated heart failure
* hepatic failure (Child-Pugh score B 이상)
* renal failure (eGFR MDRD \< 60 ml/min/1.73m2)
Minimum Eligible Age

20 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine,

Seoul, Seoul, South Korea

Site Status

Countries

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South Korea

Other Identifiers

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4-2014-0249

Identifier Type: -

Identifier Source: org_study_id

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