Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System
NCT ID: NCT01785446
Last Updated: 2013-02-07
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
150 participants
INTERVENTIONAL
2012-11-30
Brief Summary
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* determine the effect of dexmedetomidine on cisatracurium infusion requirements and sufentanil consumption.
* analyze the cisatracurium infusion requirements and sufentanil consumption in different age groups.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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P 1
In this group patients were aged from 20 to 45. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55.
Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
Consumption of cisatracurium and sufentanil in different age groups.
For this intervention, we compared the cisatracurium consumption, refractory index and sufentanil consumption between group P1, P2 and P3.
P 2
In this group patients were aged from 46 to 65. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55.
Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
Effect of dexmedetomidine on cisatracurium and sufentanil consumption
In this intervention we compared the cisatracurium consumption, recovery index and sufentanil consumption between P2 and D. The reason we are comparing patients in group D with P2 is that because they belong to the same age group.
Consumption of cisatracurium and sufentanil in different age groups.
For this intervention, we compared the cisatracurium consumption, refractory index and sufentanil consumption between group P1, P2 and P3.
P 3
In this group patients were aged from 66 to 85. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55.
Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
Consumption of cisatracurium and sufentanil in different age groups.
For this intervention, we compared the cisatracurium consumption, refractory index and sufentanil consumption between group P1, P2 and P3.
D
In this group patients were aged from 46to 65. Propofol infusion was used to maintain Bispectral Index (BIS) between 45 and 55.
Dexmedetomidine infusion is started at induction,a bolus dose of 0.5 µg/kg is given over the first hour which is followed by infusion of 0.4 µg/kg/hr.
Intermittent doses of sufentanil 10-20 microgram were given intra-operatively on a required basis.
Effect of dexmedetomidine on cisatracurium and sufentanil consumption
In this intervention we compared the cisatracurium consumption, recovery index and sufentanil consumption between P2 and D. The reason we are comparing patients in group D with P2 is that because they belong to the same age group.
Interventions
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Effect of dexmedetomidine on cisatracurium and sufentanil consumption
In this intervention we compared the cisatracurium consumption, recovery index and sufentanil consumption between P2 and D. The reason we are comparing patients in group D with P2 is that because they belong to the same age group.
Consumption of cisatracurium and sufentanil in different age groups.
For this intervention, we compared the cisatracurium consumption, refractory index and sufentanil consumption between group P1, P2 and P3.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Consent approval written and oral.
* Patients scheduled for elective abdominal surgery under general anesthesia.
Exclusion Criteria
* Patients with history of stroke, flaccid paralysis or other neurological disorders.
* Significant renal, hepatic or cardiac dysfunction.
* Consent refusal.
18 Years
85 Years
ALL
Yes
Sponsors
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Shehzaad Joomye
UNKNOWN
Haiyun Wang
UNKNOWN
Donglai Yan
UNKNOWN
Tianjin Medical University General Hospital
OTHER
Responsible Party
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Guolin Wang, MD, PhD, Professor
M.D. PhD. Professor
Principal Investigators
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Guolin Wang, MD, PhD, Professor
Role: PRINCIPAL_INVESTIGATOR
Tianjin Medical University General Hospital
Locations
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Tianjin Medical University General Hospital
Tianjin, Tianjin Municipality, China
Countries
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Central Contacts
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References
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Joomye S, Yan D, Wang H, Zhou G, Wang G. Consumption of Cisatracurium in different age groups, using a closed loop computer controlled system. BMC Anesthesiol. 2014 Apr 21;14:29. doi: 10.1186/1471-2253-14-29. eCollection 2014.
Other Identifiers
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Cis-123
Identifier Type: -
Identifier Source: org_study_id
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