Diet Induced Intestinal Mucosal Adaptation

NCT ID: NCT02088853

Last Updated: 2025-07-17

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 17 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-03-31
• Study Completion Date: 2014-12-31

Brief Summary

Human beings are 'omnivores' meaning that all principal components of food (i.e. the macronutrients: carbohydrates, fat, proteins) can be assimilated by the gastrointestinal tract. When the gut mucosa is exposed to dietary changes it adjusts its functional behaviour. For example, a fatty diet demands certain digestive mechanisms, whereas others are needed to take care of a carbohydrate rich diet. Such dietary induced changes in appearance and functionality of the small intestinal mucosa have been described in animals but only little is known about it in man. The present project aims at elucidating in man if a 2 weeks diet dominated by either fat or carbohydrates, but with similar energy content, is associated with changes in the small intestinal mucosal appearance and metabolic signalling capacity.

Conditions

Healthy Conditions

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

First high fat diet, then high carbohydrate diet

had; first sixty percent fat as the energy source, then sixty percent carbohydrates

Group Type: EXPERIMENTAL

high fat diet (hfd), then high carbohydrate diet

Intervention Type: DIETARY_SUPPLEMENT

Sixty % of the energy content is based on fat, then sixty % of the energy content is based on carbohydrates

First, high carb diet, then high fat diet

had; first sixty percent carbohydrates as the energy source, the sixty percent fat

Group Type: EXPERIMENTAL

high carbohydrate diet, then high fat diet

Intervention Type: DIETARY_SUPPLEMENT

Sixty % of the energy content is based on carbohydrates, then sixty % of the energy content is based on fat

Interventions

high fat diet (hfd), then high carbohydrate diet

Sixty % of the energy content is based on fat, then sixty % of the energy content is based on carbohydrates

Intervention Type: DIETARY_SUPPLEMENT

high carbohydrate diet, then high fat diet

Sixty % of the energy content is based on carbohydrates, then sixty % of the energy content is based on fat

Intervention Type: DIETARY_SUPPLEMENT

Eligibility Criteria

Inclusion Criteria

healthy volunteer not taking prescribed medications BMI ≤25 kg/m2

Exclusion Criteria

BMI ≥26 kg/m2 smoker previous or current gastrointestinal disease significant abdominal surgery pregnancy/breast feeding drug intolerance of importance (particularly opiates and midazolam used during endoscopy) history of drug addiction

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Sahlgrenska University Hospital

OTHER

Sponsor Role: collaborator

Göteborg University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Lars Fändriks, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Göteborg University

Locations

Dept of Gastrosurgical R&E, Sahlgrenska Universityhospital

Gothenburg, , Sweden

Countries

Sweden

References

Elebring E, Wallenius V, Casselbrant A, Docherty NG, Roux CWL, Marschall HU, Fandriks L. A Fatty Diet Induces a Jejunal Ketogenesis Which Inhibits Local SGLT1-Based Glucose Transport via an Acetylation Mechanism-Results from a Randomized Cross-Over Study between Iso-Caloric High-Fat versus High-Carbohydrate Diets in Healthy Volunteers. Nutrients. 2022 May 7;14(9):1961. doi: 10.3390/nu14091961.

Reference Type: DERIVED

PMID: 35565929 (View on PubMed)

Other Identifiers

BUTTER

Identifier Type: -

Identifier Source: org_study_id