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Effect of Diet on Intestinal Microbiota and Obesity Markers in Adults

NCT ID: NCT01449383

Last Updated: 2012-08-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

20 participants

Study Classification

INTERVENTIONAL

Study Start Date

2010-11-30

Study Completion Date

2012-08-31

Brief Summary

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This study aims to investigate the direct effect of high amounts of dietary fibre and high amounts of red meat in daily diet on intestinal microbiota, anthropometry and obesity markers in healthy adults.

Detailed Description

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Human gut microbiota composition and its bacterial pathways are involved in many metabolic processes, including digestion of actually indigestible food components and fat storage. Due to that it may contributes to the developement of obesity being one of the most important risk factors for many chronic diseases. Gut microbiota is under the influence of nutrition, consumption of pro- and prebiotics can promote the growth of certain bacterial strains. In a cross over dietary intervention this work will investigate the effect of defined diets on the intestinal microbiota in 20 healthy adults. The diets contain either high amounts (more than 40g/d) of dietary fibre and low red meat (less than 30g/d) or low amounts (less than 20g/d) of dietary fibre and high amounts of red meat (200g/d). Intervention periods last 3 weeks each interrupted by a 3 weeks wash out period. Examination of participants will happen at the beginning and at the end of both interventions and will contain anthropometry, blood sample, faecal sample, urine sample and saliva sample.

Conditions

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Intestinal Microbiota Blood Markers

Keywords

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cross over dietary intervention fibre red meat microbiota

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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low meat high fibre (lmhf)

consumption of less than 30g red meat per day and at least 40g dietary fibre per day

Group Type ACTIVE_COMPARATOR

low meat high fibre

Intervention Type DIETARY_SUPPLEMENT

less than 30g red meat and at least 40g dietary fibre per day

high meat low fibre (hmlf)

consumption of 200g red meat and not more than 20g dietary fibre per day

Group Type ACTIVE_COMPARATOR

high meat low fibre

Intervention Type DIETARY_SUPPLEMENT

at least 200g red meat (pork, beef or other mammals) and not more than 20g dietary fibre per day

Interventions

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low meat high fibre

less than 30g red meat and at least 40g dietary fibre per day

Intervention Type DIETARY_SUPPLEMENT

high meat low fibre

at least 200g red meat (pork, beef or other mammals) and not more than 20g dietary fibre per day

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* age 20 to 60
* obtained informed consent
* willing and able to consume defined diets
* willing and able to collect all intended samples

Exclusion Criteria

* prevalent chronic disease, i.e. diabetes (type 1 and 2), cardiovascular diseases, cancer
* Antibiotic treatment within the last three month before start of studies
* Prevalent gastrointestinal diseases, disorders and surgeries
* Pregnancy and breastfeeding
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Umeå University

OTHER

Sponsor Role collaborator

Quadram Institute Bioscience

OTHER

Sponsor Role collaborator

VTT Technical Research Centre of Finland

OTHER

Sponsor Role collaborator

German Institute of Human Nutrition

OTHER

Sponsor Role lead

Responsible Party

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Jana Foerster

Jana Foerster, PhD student

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jana Foerster, PhD student

Role: PRINCIPAL_INVESTIGATOR

German Institute of Human Nutrition Potsdam-Rehbruecke

Countries

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Germany

References

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Foerster J, Maskarinec G, Reichardt N, Tett A, Narbad A, Blaut M, Boeing H. The influence of whole grain products and red meat on intestinal microbiota composition in normal weight adults: a randomized crossover intervention trial. PLoS One. 2014 Oct 9;9(10):e109606. doi: 10.1371/journal.pone.0109606. eCollection 2014.

Reference Type DERIVED
PMID: 25299601 (View on PubMed)

Other Identifiers

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KBBE-2007-2-2-07_WP2.4

Identifier Type: -

Identifier Source: org_study_id