Muscle Blood Flow During Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-09-01

Study Completion Date

2018-10-19

Brief Summary

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Physical exercise triggers various physiological responses including a marked increase in muscle blood flow and oxygen delivery in order to support muscle activity. How muscle blood flow is controlled is currently unclear.

The primary purpose of this study is to establish the respective contribution of metabolic (linked to energy requirements) and mechanical (linked to muscle tensions) signals in the exercise hyperemia and the possible role of the red blood cells.

Vasodilation and muscle blood flow during exercise are controlled by ATP released in the plasma from the red blood cells in response to a combination of metabolic and mechanical signals applied on the vasculature.

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Detailed Description

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Conditions

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Skeletal Muscle Blood Flow

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Concentric vs eccentric

One arm study in which each subject will act as his own control.

Session 1-4

Intervention Type OTHER

Familiarization sessions to knee-extensor exercise separated by 72h recovery

Session 4

Intervention Type OTHER

After the last familiarization session, 1 maximal incremental test on a bicycle, followed by 72h rest

Session 5

Intervention Type OTHER

2 maximal incremental tests of knee-extension exercise (concentric vs eccentric), separated by 3h rest.

Interventions

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Session 1-4

Familiarization sessions to knee-extensor exercise separated by 72h recovery

Intervention Type OTHER

Session 4

After the last familiarization session, 1 maximal incremental test on a bicycle, followed by 72h rest

Intervention Type OTHER

Session 5

2 maximal incremental tests of knee-extension exercise (concentric vs eccentric), separated by 3h rest.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Non smoker or having stopped smoking for at least 5 yr
* Practice sports: physical activity level will be evaluated with a questionnaire (de Baecke et coll., 1982) and will give an activity index greater than 6 together with a VO2max greater than 50 ml/kg/min
* Body mass index lower than 25
* Registered to the French Social Security system
* Providing a written and informed consent to participate in the study

Exclusion Criteria

* History of venous or arterial thrombo-embolic events
* Bad perfusion from the cubital artery
* Unable to understand the information notice
* Subject exposed to law investigations or with financial dependancy
* Subjects feeling unwell whan seing blood.
* Subjects advised to not practice sport.
* Musculo-tendinous or articular issues with the lower leg
* Respiratory, cardiovascular or metabolic pathologies
* Current medical treatment that can not be stopped 7 days before the experiment.

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes