Respiratory Muscle Contribution to Blood Pressure During Exercise

NCT ID: NCT03514823

Last Updated: 2021-07-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

38 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-01

Study Completion Date

2019-09-25

Brief Summary

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The investigators seek to understand how reflexes from the breathing muscles influence blood pressure during exercise. Furthermore, the investigators are determining if increasing breathing muscle strength (via inspiratory muscle training) influences the respiratory muscle contribution to blood pressure during exercise.

Detailed Description

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Conditions

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Respiratory Muscle Blood Pressure Exercise Capacity Sympathetic Nerve Activity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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IMT Group

Group Type EXPERIMENTAL

Inspiratory Muscle Training (IMT)

Intervention Type OTHER

Inspiratory muscle training (IMT) are breathing exercises used to increase strength and endurance of the respiratory muscles.

No IMT Group

Group Type SHAM_COMPARATOR

No Inspiratory Muscle Training (IMT)

Intervention Type OTHER

No inspiratory muscle training.

Interventions

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Inspiratory Muscle Training (IMT)

Inspiratory muscle training (IMT) are breathing exercises used to increase strength and endurance of the respiratory muscles.

Intervention Type OTHER

No Inspiratory Muscle Training (IMT)

No inspiratory muscle training.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Healthy participants with no history of cardiovascular, pulmonary, neurologic, orthopedic or other neuromuscular diseases.
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Heart, Lung, and Blood Institute (NHLBI)

NIH

Sponsor Role collaborator

Mayo Clinic

OTHER

Sponsor Role lead

Responsible Party

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Thomas P. Olson, M.S., Ph.D.

Associate Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Thomas P Olson

Role: PRINCIPAL_INVESTIGATOR

Mayo Clinic

Locations

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Mayo Clinic

Rochester, Minnesota, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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5R01HL126638-03

Identifier Type: NIH

Identifier Source: secondary_id

View Link

17-011100

Identifier Type: -

Identifier Source: org_study_id

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