Muscle Training Induced Angiogenesis in COPD

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

22 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-01-31

Study Completion Date

2016-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

COPD patients experiment a peripheral muscle dysfunction which impact their exercise tolerance and health-related quality of life. The capillary to fiber interface is reduced and impact the exercise capacity of the patients. While the muscle capillary creation in response to exercise training is blunted in COPD patients, the maturation of the neo-capillaries could also be blunted and contribute to the impaired aniogionenesis in patients. Because the capillary maturation is a sensitive and dynamic process, only different modalities of exercise training and multiple time-points of measures would allow to capture this microvascular adaptation.

Aim of the study : Compare the muscle capillary maturation in response to training at 5 and 10 weeks, in sedentary healthy subject trained at the intensity of the ventilatory threshold (60-65% of VO2max), versus :- COPD patients trained at a similar intensity (60-65% of VO2max)- COPD patients trained at a similar absolute intensity (90% of VO2max).

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Effects of Inspiratory Muscle Training in COPD

NCT01397396

COPD Inspiratory Muscle Weakness

COMPLETED PHASE3

Skeletal Muscle Function in Interstitial Lung Disease

NCT03800017

Interstitial Lung Disease Idiopathic Pulmonary Fibrosis Hypersensitivity Pneumonitis +2 more

RECRUITING NA

Inspiratory Muscle Training in Chronic Obstructive Pulmonary Disease

NCT01056081

Chronic Obstructive Pulmonary Disease

COMPLETED PHASE3

Effect of Inspiratory Muscle Training During PR on Dyspnoea and Exercise Tolerance in COPD Patients

NCT04120142

Chronic Obstructive Pulmonary Disease

COMPLETED NA

Effects of Inspiratory Muscle Training on Breathing Pattern in Patients With Chronic Obstructive Pulmonary Disease

NCT02186340

Chronic Obstructive Pulmonary Disease Muscle Weakness Conditions

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Peripheral Muscle Dysfunction COPD

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

TRIPLE

Participants Caregivers Outcome Assessors

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

COPD Patients ~90% VO2max

COPD Patients \~90% VO2max

Group Type ACTIVE_COMPARATOR

Muscular biopsy

Intervention Type PROCEDURE

COPD patients ~60-65% VO2max

COPD patients \~60-65% VO2max

Group Type ACTIVE_COMPARATOR

Muscular biopsy

Intervention Type PROCEDURE

healthy volunteers

Group Type PLACEBO_COMPARATOR

Muscular biopsy

Intervention Type PROCEDURE

5-10 weeks sport training

Intervention Type OTHER

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Muscular biopsy

Intervention Type PROCEDURE

5-10 weeks sport training

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* COPD patients :
* FEV1\<80%pred.
* non exacerbation during the past 4 weeks
* no oxygen therapy, -

Healthy subjects:

* \<150min/week of moderate-to-vigorous physical activity,
* Voorrips score \<9

Exclusion Criteria

* Unstable comorbidity
* Long term oxygen therapy or ventilation
* Rehabilitation program during the past 12 months
* nutritional supplementation during the past 4 weeks
* allopurinol or N-acetylcystein during the past 4 weeks
* long corticosteroid treatment during the past 6 months
* hyperreactivity to xylocain
* anticoagulant or platelet aggregation inhibitors treatment
* participation to an other research study-pregnancy or impossibility to provide informed consent, ...

Minimum Eligible Age

40 Years

Maximum Eligible Age

78 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes