Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
30 participants
INTERVENTIONAL
2019-12-27
2023-01-28
Brief Summary
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The primary outcome of this randomized pilot study is knee extensor muscle strength. Secondary, the study will evaluate if LL-BFRT is well tolerated and feasible in COPD patients attending outpatient pulmonary rehabilitation.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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LL-BFRT group
Participants randomised into intervention group are attending pulmonary rehabilitation in which strengthening exercises of the lower limb are performed using LL-BFRT.
Low-load blood flow restriction training
The intervention group will perform the exercises of the lower limbs using LL-BFRT with an occlusion pressure of 70% of arterial occlusion pressure with low training loads (30% of the 1 repetition maximum).
Usual pulmonary rehabilitation group
Participants randomised into control group are attending usual pulmonary rehabilitation as established.
Usual outpatient pulmonary rehabilitation
The control group will perform outpatient pulmonary rehabilitation as established.
Interventions
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Low-load blood flow restriction training
The intervention group will perform the exercises of the lower limbs using LL-BFRT with an occlusion pressure of 70% of arterial occlusion pressure with low training loads (30% of the 1 repetition maximum).
Usual outpatient pulmonary rehabilitation
The control group will perform outpatient pulmonary rehabilitation as established.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Assigned to outpatient pulmonary rehabilitation by the treating physician
Exclusion Criteria
* Non-German speaking (precluding informed consent)
* Acute or recent (within the last 6 weeks) exacerbation of COPD
* Attending a pulmonary rehabilitation program within the last 3 months
* Pregnant patients
* History of thromboembolic event in the lower extremity
* Diagnosis of polyneuropathy
* Resting systolic blood pressure \<100 mmHg
40 Years
ALL
No
Sponsors
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University of Zurich
OTHER
Responsible Party
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Locations
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University Hospital Zurich
Zurich, , Switzerland
Countries
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References
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Kohlbrenner D, Kuhn M, Manettas A, Aregger C, Peterer M, Greco N, Sievi NA, Clarenbach C. Low-load blood flow restriction strength training in patients with COPD: a randomised single-blind pilot study. Thorax. 2024 Mar 15;79(4):340-348. doi: 10.1136/thorax-2023-220546.
Other Identifiers
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SNCTP000003509
Identifier Type: OTHER
Identifier Source: secondary_id
2019-01641
Identifier Type: OTHER
Identifier Source: secondary_id
2019-01641
Identifier Type: -
Identifier Source: org_study_id
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