The Acute Effect of Interval-walking

NCT ID: NCT01987258

Last Updated: 2014-02-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-06-30

Study Completion Date

2014-02-28

Brief Summary

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Four months of interval walking training (IWT) is superior to energy-expenditure matched continuous walking training (CWT) with regards to weight loss and improvements in glycemic control. The reason for this is unclear. One potential explanation for the differential outcome in weight loss is excess post-exercise oxygen consumption (EPOC), which is defined as the elevated oxygen consumption measured during the hours following an exercise bout. A large EPOC means greater energy expenditure which, if energy intake does not change, leads to a greater weight loss. This weight loss may subsequently improve glycemic control

* Aim 1: To assess the effect of an acute bout of IWT vs. an acute bout of CWT on glycemic control in type 2 diabetics and to assess mechanisms responsible for differences (if any). It is hypothesised that IWT will be more advantageous for improving glycemic control.
* Aim 2: To examine the effect of an acute bout of IWT vs. an acute bout of CWT on EPOC. It is hypothesised that IWT will produce an EPOC of larger magnitude than CWT.

Detailed Description

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Conditions

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Type 2 Diabetes Mellitus

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control

No exercise (control experiment)

Group Type NO_INTERVENTION

No interventions assigned to this group

Interval Walking

A one hour interval walking exercise bout

Group Type EXPERIMENTAL

Interval Walking

Intervention Type BEHAVIORAL

Continuous walking

A one hour continuous walking exercise bout

Group Type EXPERIMENTAL

Continuous walking

Intervention Type BEHAVIORAL

Interventions

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Interval Walking

Intervention Type BEHAVIORAL

Continuous walking

Intervention Type BEHAVIORAL

Other Intervention Names

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Interval exercise Interval training Continuous exercise Continuous training

Eligibility Criteria

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Inclusion Criteria

* Diabetes mellitus, type 2

Exclusion Criteria

* Smoking
* Pregnancy
* insulin dependence
* Contraindication to physical activity (as judged by medical history and screening)
* Evidence of thyroid, liver, lung, kidney or heart disease
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Inge Holm

Administrator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kristian Karstoft, MD

Role: PRINCIPAL_INVESTIGATOR

Centre of Inflammation and Metabolism (CIM), Rigshospitalet, Tagensvej 20, section M7641, DK-2100 Copenhagen, Denmark

Locations

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Centre of Inflammation and Metabolism (CIM), Rigshospitalet, Tagensvej 20, section M7641

Copenhagen, , Denmark

Site Status

Countries

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Denmark

References

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Karstoft K, Christensen CS, Pedersen BK, Solomon TP. The acute effects of interval- Vs continuous-walking exercise on glycemic control in subjects with type 2 diabetes: a crossover, controlled study. J Clin Endocrinol Metab. 2014 Sep;99(9):3334-42. doi: 10.1210/jc.2014-1837. Epub 2014 Jun 6.

Reference Type DERIVED
PMID: 24905068 (View on PubMed)

Other Identifiers

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H-3-2012-141

Identifier Type: -

Identifier Source: org_study_id

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