Interval-training and Appetite Regulation in Patients With Type 2 Diabetes

NCT ID: NCT02592616

Last Updated: 2016-06-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

14 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-10-31

Study Completion Date

2016-10-31

Brief Summary

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Four months of interval walking (IW) training results in substantial weight loss in opposition to energy-expenditure matched continuous walking (CW) training. The reason for this is unclear.

This study will assess if IW leads to greater exercise-induced suppression of appetite and ad libitum food intake compared to CW and no exercise.

Subjects with type 2 diabetes will be included in a crossover, counter-balanced, controlled study, where each subject will undergo three trials. Trials will be identical except the following interventions:

1. One hour of rest (CON)
2. One hour of interval walking (repeated cycles of 3 min of fast and 3 min of slow walking; IW)
3. One hour of continuous walking (CW) matched to IW with regards to energy-expenditure.

After the interventions subjects will undergo a liquid mixed meal tolerance test (450 kCal), with regular measurements of appetite-related hormones (insulin, ghrelin, Leptin, Cholecystokinin, PYY). Three hours into the mixed meal tolerance test, a standardised ad-libitum meal test will be served and intake will recorded. Free-living energy intake via food records will be assessed during the following 32 hours.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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CON

Control (CON).

Group Type EXPERIMENTAL

CON

Intervention Type BEHAVIORAL

No exercise intervention.

CW

Continuous Walking (CW).

Group Type EXPERIMENTAL

CW

Intervention Type BEHAVIORAL

One hour of continuous walking on a treadmill.

IW

Interval Walking (IW).

Group Type EXPERIMENTAL

IW

Intervention Type BEHAVIORAL

One hour of interval (repeated cycles of 3 minutes of fast and 3 minutes of slow) walking on treadmill.

Interventions

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CON

No exercise intervention.

Intervention Type BEHAVIORAL

CW

One hour of continuous walking on a treadmill.

Intervention Type BEHAVIORAL

IW

One hour of interval (repeated cycles of 3 minutes of fast and 3 minutes of slow) walking on treadmill.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Type 2 Diabetes Mellitus
* BMI \> 25

Exclusion Criteria

* Pregnancy
* Smoking
* Contraindication to increased levels of physical activity
* Eating disorder
* Insulin dependence
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Anders Rasmussen Rinnov

MD, PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Center for Physical Activity Research (CFAS)

Copenhagen, , Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H-15008542

Identifier Type: -

Identifier Source: org_study_id

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