Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
14 participants
INTERVENTIONAL
2014-11-30
2016-04-30
Brief Summary
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The overall objective of this project is to determine the mechanisms underlying aeroic interval-training-induced reductions in glycemic variability and -spikes, and the impact on levels of systemic inflammation in type 2 diabetes patients. It is hypothesized that aerobic interval training reduces glycemic variability and -spikes more than continuous training due to larger improvements in both peripheral insulin sensitivity and the mass action effect of glucose. Moreover, it is hypothesized that these reductions in glycemic variability and -spikes also reduces systemic inflammation.
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Control
Control intervention: Subjects will continue their life unaltered during the 14 days intervention period
Control
Continuous walking
Training intervention: Subjects will perform continuous walking for one hour per day at every weekday during the 14 days intervention period
Continuous walking
Interval Walking
Training intervention: Subjects will perform interval walking for one hour per day at every weekday during the 14 days intervention period. Interval walking will be performed as repeated cycles of three minutes of slow and hree minutes of fast walking during the entire training session
Interval walking
Interventions
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Control
Continuous walking
Interval walking
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* BMI \>18 but \<40 kg/m2
Exclusion Criteria
* Smoking
* Contraindication to increased levels of physical activity
* More than moderate levels of physical activity (\>90 min/week) of maximally moderate intensity
* Insulin dependence
* Thyroid, liver, lung, heart or kidney disease, with the need for treatment
40 Years
ALL
No
Sponsors
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Rigshospitalet, Denmark
OTHER
Responsible Party
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Anders Rasmussen Rinnov
MD, PhD
Principal Investigators
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Kristian Karstoft, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Rigshospitalet, The Centre for Physical Activity Research
Locations
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The Centre for Physical Activity Research, Rigshospitalet
Copenhagen, , Denmark
Countries
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References
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Karstoft K, Clark MA, Jakobsen I, Knudsen SH, van Hall G, Pedersen BK, Solomon TPJ. Glucose effectiveness, but not insulin sensitivity, is improved after short-term interval training in individuals with type 2 diabetes mellitus: a controlled, randomised, crossover trial. Diabetologia. 2017 Dec;60(12):2432-2442. doi: 10.1007/s00125-017-4406-0. Epub 2017 Aug 25.
Karstoft K, Brinklov CF, Thorsen IK, Nielsen JS, Ried-Larsen M. Resting Metabolic Rate Does Not Change in Response to Different Types of Training in Subjects with Type 2 Diabetes. Front Endocrinol (Lausanne). 2017 Jun 13;8:132. doi: 10.3389/fendo.2017.00132. eCollection 2017.
Karstoft K, Clark MA, Jakobsen I, Muller IA, Pedersen BK, Solomon TP, Ried-Larsen M. The effects of 2 weeks of interval vs continuous walking training on glycaemic control and whole-body oxidative stress in individuals with type 2 diabetes: a controlled, randomised, crossover trial. Diabetologia. 2017 Mar;60(3):508-517. doi: 10.1007/s00125-016-4170-6. Epub 2016 Dec 9.
Other Identifiers
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H-6-2014-043
Identifier Type: -
Identifier Source: org_study_id
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