Post-Approval Clinical Trial of the PCM® Cervical Disc

NCT ID: NCT01905930

Last Updated: 2015-05-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

494 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2015-04-30

Brief Summary

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On October 26, 2012, the FDA granted Premarket Approval (PMA) for the PCM Cervical Disc. PCM Cervical Disc is indicated for use in skeletally mature patients for reconstruction of a degenerated cervical disc at one level from C3-C4 to C6-C7 following single-level discectomy for intractable radiculopathy (arm pain and/or a neurological deficit), with or without neck pain, or myelopathy due to a single-level abnormality localized to the disc space, and manifested by at least one of the following conditions confirmed by radiographic imaging (CT, MRI, X-rays): herniated nucleus pulposus, spondylosis (defined by the presence of osteophytes), and/or visible loss of disc height as compared to adjacent levels.

The purpose of this post-approval study is to evaluate the long-term (7 year) safety and effectiveness of the PCM Cervical Disc.

Detailed Description

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A prospective, multi-center, post approval study with concurrent control group consisting of those patients that were enrolled and did not fail in the PCM Cervical Disc IDE clinical study and will to give consent to participate.

All of the PCM IDE investigational sites who have active patients will be chosen to participate in this study. All patients who are actively participating in the pivotal IDE study will be asked to participate in this study.

The study consists of follow-up periods only. The follow-up period will last for seven years from each patient's surgery date.

Conditions

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Radiculopathy Myelopathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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PCM Cervical Disc

Patients enrolled in the IDE clinical study and treated with the PCM Cervical Disc to treat degenerated cervical discs and neurological symptoms at one level from C3 to T1

Group Type EXPERIMENTAL

PCM Cervical Disc

Intervention Type DEVICE

Patients enrolled in the IDE clinical study and treated with the PCM Cervical Disc to treat degenerated cervical discs and neurological symptoms at one level from C3 to T1

Ant. Cervical Discectomy & Fusion(ACDF)

Patients enrolled in the IDE clinical study and treated with an anterior cervical discectomy and fusion (ACDF) using a cervical plate and bone graft in patients with degenerated cervical discs and neurological symptoms at one level from C3 to T1

Group Type ACTIVE_COMPARATOR

Anterior Cervical Discectomy and Fusion (ACDF)

Intervention Type DEVICE

Patients enrolled in the IDE clinical study and treated with an anterior cervical discectomy and fusion (ACDF) using a cervical plate and bone graft in patients with degenerated cervical discs and neurological symptoms at one level from C3 to T1

Interventions

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PCM Cervical Disc

Patients enrolled in the IDE clinical study and treated with the PCM Cervical Disc to treat degenerated cervical discs and neurological symptoms at one level from C3 to T1

Intervention Type DEVICE

Anterior Cervical Discectomy and Fusion (ACDF)

Patients enrolled in the IDE clinical study and treated with an anterior cervical discectomy and fusion (ACDF) using a cervical plate and bone graft in patients with degenerated cervical discs and neurological symptoms at one level from C3 to T1

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patients enrolled in the PCM Cervical Disc IDE clinical study
* Patients willing and able to give informed consent

Exclusion Criteria

* Patients considered failure during the PCM Cervical Disc IDE clinical study
* Patients who were withdrawn during the PCM Cervical Disc IDE clinical study
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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NuVasive

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Spine Group Beverly Hills

Beverly Hills, California, United States

Site Status

Denver Spine

Greenwood Village, Colorado, United States

Site Status

Midwest Orthopedic Associates at Rush

Chicago, Illinois, United States

Site Status

Chicago Back Institute

Chicago, Illinois, United States

Site Status

Goodman Campbell Brain and Spine

Indianapolis, Indiana, United States

Site Status

Towson Orthopedic Associates

Towson, Maryland, United States

Site Status

Wm. Beaumont Hospital

Southfield, Michigan, United States

Site Status

Columbia Orthopedic Research

Columbia, Missouri, United States

Site Status

Buffalo Spine Surgery

Lockport, New York, United States

Site Status

Institute for Spine Care

Syracuse, New York, United States

Site Status

The Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Neuroscience Specialists

Oklahoma City, Oklahoma, United States

Site Status

The Rothman Institute

Philadelphia, Pennsylvania, United States

Site Status

Scott and White Memorial Hospital

Temple, Texas, United States

Site Status

Virginia Brain and Spine

Winchester, Virginia, United States

Site Status

Olympia Othopaedic Associates

Olympia, Washington, United States

Site Status

Madigan Army Medical Center

Tacoma, Washington, United States

Site Status

NeuroSpine Center of Wisconsin

Appleton, Wisconsin, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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NUVA-PCM-1101

Identifier Type: -

Identifier Source: org_study_id

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