M6-C Post Approval Study (PAS)

NCT ID: NCT04122248

Last Updated: 2025-07-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Total Enrollment

152 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-30

Study Completion Date

2026-06-30

Brief Summary

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The M6-C Post Approval Study is a long term follow-up study of subjects previously enrolled and treated in the M6-C Artificial Cervical Disc IDE Study.

Detailed Description

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A prospective, concurrently controlled, multi-center pivotal study to evaluate the safety and effectiveness of the M6-C™ Artificial Cervical Disc compared to anterior cervical discectomy and fusion (ACDF) was performed in the United States under IDE #G050254. To fulfill the concurrent control design of the study, there were clinical sites that evaluated the safety and effectiveness of the M6-C™ Artificial Cervical Disc and there were other clinical sites that evaluated ACDF. Subjects in the study were treated between May 2014 and June 2016 and remain in follow-up. The M6-C™ Artificial Cervical Disc received FDA approval to market on February 6, 2019. As a condition of approval, the FDA requested that the sponsor perform a post market approval study (PAS). The subjects enrolled and remaining in the M6-C IDE pivotal study are the prospective patient population for the PAS.

Conditions

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Cervical Degenerative Disc Disease Cervical Radiculopathy Cervical Spinal Cord Compression Cervical Disc Herniation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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M6-C

Subjects treated with an M6-C device

standard radiographic imaging

Intervention Type OTHER

standard radiographic imaging

cervical total disc replacement

Intervention Type DEVICE

Artificial disc replacement (ADR) in the cervical spine is a minimally invasive procedure that involves removing diseased disc tissue and replacing it with an artificial disc. The artificial disc is designed to preserve the spine\'s natural motion while remaining securely attached to the surrounding vertebral bones. The goal of ADR is to help preserve the motion of the cervical spine or spinal segment after surgery, which can improve the quality of life for patients.

ACDF

Subjects treated with Anterior Cervical Discectomy and Fusion (ACDF)

standard radiographic imaging

Intervention Type OTHER

standard radiographic imaging

Interventions

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standard radiographic imaging

standard radiographic imaging

Intervention Type OTHER

cervical total disc replacement

Artificial disc replacement (ADR) in the cervical spine is a minimally invasive procedure that involves removing diseased disc tissue and replacing it with an artificial disc. The artificial disc is designed to preserve the spine\'s natural motion while remaining securely attached to the surrounding vertebral bones. The goal of ADR is to help preserve the motion of the cervical spine or spinal segment after surgery, which can improve the quality of life for patients.

Intervention Type DEVICE

Other Intervention Names

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cervical disc arthroplasty cervical artificial disc replacement

Eligibility Criteria

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Exclusion Criteria

* Subjects who were withdrawn or withdrew consent to participate in the investigation
* Subjects who do not consent to participate in long-term follow-up or provide personal contact information to the sponsor (solely for the purposes of tracking subjects to help ensure follow-up compliance)
* Patients with terminal failures (SSI or device- or procedure-related SAE) by Month 24 and all known patient deaths in the M6-C IDE study are excluded for enrollment into the PAS
Minimum Eligible Age

21 Years

Maximum Eligible Age

68 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Spinal Kinetics

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Desert Institute for Spine Care

Phoenix, Arizona, United States

Site Status

The CORE Institute

Sun City West, Arizona, United States

Site Status

Spine MD

Beverly Hills, California, United States

Site Status

Memorial Orthopedic Surgical Group

Long Beach, California, United States

Site Status

Stanford University

Stanford, California, United States

Site Status

University of Colorado School of Medicine

Aurora, Colorado, United States

Site Status

ClinTech Center for Spine

Johnstown, Colorado, United States

Site Status

Yale University School of Medicine

New Haven, Connecticut, United States

Site Status

Medstar Hospital/Georgetown University

Washington D.C., District of Columbia, United States

Site Status

Midwest Orthopedics

Chicago, Illinois, United States

Site Status

Indiana Spine Group

Carmel, Indiana, United States

Site Status

Spine Institute of Lousianna

Shreveport, Louisiana, United States

Site Status

HSS

New York, New York, United States

Site Status

Upstate Medical University

Syracuse, New York, United States

Site Status

CNSA

Charlotte, North Carolina, United States

Site Status

OrthoCarolina Research Institute

Charlotte, North Carolina, United States

Site Status

EmergeOrtho

Durham, North Carolina, United States

Site Status

The Ohio State University - Wexner Medical Center

Columbus, Ohio, United States

Site Status

Center for Sports Medicine & Orthopedics

Chattanooga, Tennessee, United States

Site Status

Texas Back Institute

Plano, Texas, United States

Site Status

West Virginia University

Morgantown, West Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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CA-C004

Identifier Type: -

Identifier Source: org_study_id

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