Pilot Study for Noninvasive Spectroscopic Detection of Adipose Tissue Inflammation in Obesity

NCT ID: NCT01900366

Last Updated: 2016-09-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

14 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-08-31

Study Completion Date

2016-08-31

Brief Summary

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This study will test the potential of two techniques using light properties of adipose tissue to diagnose crown-like structures and inflammation to be compared with pathologic examination of adipose tissue biopsies from ongoing clinical studies.

Detailed Description

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Adipose tissue (fat) inflammation is emerging as an important harbinger of disease development including Type 2 diabetes, heart disease and potentially cancer. The hallmark feature of adipose tissue inflammation is the crown-like structure, a dying fat cell surrounded by immune cells attempting to clear the damage. Current methods for detecting adipose tissue inflammation rely on invasive procedures such as fat biopsies. We propose developing methods that use the light reflection properties of inflamed adipose tissue as a potential non-invasive method to detect adipose tissue inflammation.

Conditions

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Obesity

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Obese subjects for fat biopsy

10 patients recruited during fat biopsies for sample collection

Fat Biopsy

Intervention Type PROCEDURE

Fat biopsy

Lean controls for fat biopsy

5 Lean controls will be recruited

Fat Biopsy

Intervention Type PROCEDURE

Fat biopsy

Interventions

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Fat Biopsy

Fat biopsy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

-Subjects currently enrolled in a current Rockefeller University study who will be undergoing adipose tissue biopsies as part of the study protocol

Exclusion Criteria

-History of any skin disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Weill Medical College of Cornell University

OTHER

Sponsor Role collaborator

Rockefeller University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jose Aleman, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Rockefeller Univesrity

Locations

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The Rockefeller University

New York, New York, United States

Site Status

Countries

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United States

Other Identifiers

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JAL-0809

Identifier Type: -

Identifier Source: org_study_id

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