Ectopic Lipid Deposition and Insulin Resistance in After Treatment of Acromegaly

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

40 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-04-30

Study Completion Date

2016-03-30

Brief Summary

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This study investigates fat distribution in people with acromegaly. The investigator is also investigating the change of fat distribution before and after treatment of acromegaly. The investigator will compare the results of people with acromegaly to the results of healthy volunteers.

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Volunteers

RECRUITING

Detailed Description

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Conditions

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Acromegaly

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Active Acromegaly

All study subjects with acromegaly will be studied twice - once during the active stage of their disease (pre-treatment) and a second time: 3 months after treatment of acromegaly. Controls will be studied at one time point.

No interventions assigned to this group

Healthy controls

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Ages 18 - 75 yr (both groups)
* Study subjects with active acromegaly
* Healthy controls

Exclusion Criteria

* Serum creatinine or alanine aminotransferase (ALT) \> 2 times the upper limit of normal, metastatic cancer.
* Controls will be receiving no medications and have no chronic diseases, including cancer, hypertension or diabetes mellitus.
* Contraindications to MRI imaging (both groups) like those with certain metal implants, surgical clips or pacemakers.
* Pregnant women

Minimum Eligible Age

18 Years

Maximum Eligible Age

75 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes