Investigating the Effect of Obesity on Eosinophil Recruitment in Human Adipose Tissue

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-01-29

Study Completion Date

2022-01-17

Brief Summary

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Researchers are trying to better understand the relationship between inflammation in adipose tissue (AT) and insulin resistance.

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Detailed Description

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Conditions

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Obese Healthy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Lean, Healthy Controls

Subjects with a body mass index (BMI) of 25 or less will have a fat tissue biopsy collected

Group Type ACTIVE_COMPARATOR

Fat Tissue Biopsy

Intervention Type PROCEDURE

If subjects are scheduled for a surgical procedure a fat sample will be collected during the beginning of the surgery. If subjects are not scheduled for a surgical procedure, a small sample of subcutaneous (superficial) fat tissue from subjects abdomen area will be collected.

Obese, Non-Diabetic

Subject with a BMI between 30 and 50 kg/m2 will have fat tissue biopsy collected

Group Type EXPERIMENTAL

Fat Tissue Biopsy

Intervention Type PROCEDURE

If subjects are scheduled for a surgical procedure a fat sample will be collected during the beginning of the surgery. If subjects are not scheduled for a surgical procedure, a small sample of subcutaneous (superficial) fat tissue from subjects abdomen area will be collected.

Interventions

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Fat Tissue Biopsy

If subjects are scheduled for a surgical procedure a fat sample will be collected during the beginning of the surgery. If subjects are not scheduled for a surgical procedure, a small sample of subcutaneous (superficial) fat tissue from subjects abdomen area will be collected.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Adults ages 30-50 years
* Non-smokers
* Lean subjects with a BMI of 25 or less, gender specific normal body fat,
* Obese, non-diabetic subjects with a BMI between 30 and 50 and taking no medications affecting glucose metabolism or lipid metabolism
* subjects scheduled for an elective laparoscopic or laparotomy abdominal surgery

Exclusion Criteria

* Receiving corticosteroid therapy or have a history of asthma, COPD or atopic syndrome
* taking any biologic treatment for any autoimmune disorder
* Taking any leukotriene receptor antagonist acting medications (ex. Montelukast)
* smoking

Minimum Eligible Age

30 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes