Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
120 participants
OBSERVATIONAL
2023-09-22
2029-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Lean Group
Participants with body mass index 20-25 kg/m\^2 will complete an outpatient study visit (body composition, blood draw, treadmill test, strength test) and an inpatient visit (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).
Treadmill Test
Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).
Strength Test
Measure the strength of leg muscles by kicking against a machine with resistance.
Dual-Energy X-Ray Absorptiometry
Body composition measurement.
Muscle Biopsy
Obtain a small piece of muscles from the upper part of the legs
Fat Biopsy
Fat sample taken from abdomen
Resting Energy Expenditure
Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.
Magnetic resonance imaging
MRI on upper leg to look at fat and muscle
Obese Group
Participants with body mass index 30-45 kg/m\^2 will complete an outpatient study visit (body composition, blood draw, treadmill test, strength test) and an inpatient visit (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).
Treadmill Test
Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).
Strength Test
Measure the strength of leg muscles by kicking against a machine with resistance.
Dual-Energy X-Ray Absorptiometry
Body composition measurement.
Muscle Biopsy
Obtain a small piece of muscles from the upper part of the legs
Fat Biopsy
Fat sample taken from abdomen
Resting Energy Expenditure
Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.
Magnetic resonance imaging
MRI on upper leg to look at fat and muscle
Interventions
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Treadmill Test
Measurement of whole-body fitness level. Walking or running on a treadmill and breathing into a machine that measures oxygen level during test. Heart rhythm is continuously monitored during exercise using an electrocardiogram (ECG).
Strength Test
Measure the strength of leg muscles by kicking against a machine with resistance.
Dual-Energy X-Ray Absorptiometry
Body composition measurement.
Muscle Biopsy
Obtain a small piece of muscles from the upper part of the legs
Fat Biopsy
Fat sample taken from abdomen
Resting Energy Expenditure
Measured by indirect calorimetry. Measures how much energy the body uses at rest by placing a special plastic dome over the head while resting quietly for 30 minutes. Measures oxygen breathed in and carbon dioxide breathed out.
Magnetic resonance imaging
MRI on upper leg to look at fat and muscle
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
* Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
* Renal failure (serum creatinine \> 1.5mg/dl)
* Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
* Oral warfarin group medications or history of blood clotting disorders.
* Smoking
* Pregnancy or breastfeeding
* Alcohol consumption greater than 2 glasses/day or other substance abuse
* Untreated or uncontrolled hypothyroidism
* Debilitating chronic disease (at the discretion of the investigators)
20 Years
45 Years
ALL
No
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Ian R. Lanza
Principal Investigator
Principal Investigators
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Ian Lanza, PhD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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22-012396
Identifier Type: -
Identifier Source: org_study_id
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