Effect of Body Composition and Metabolism on Oocyte Gene Expression

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

46 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-04-30

Study Completion Date

2019-05-02

Brief Summary

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The investigators will test the hypothesis that obese women have a unique oocyte gene expression profile that differs significantly from that of normal weight women.

Detailed Description

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Conditions

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Healthy

Keywords

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healthy women oocytes in vitro fertilization pregnancy childbearing-age

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* BMI \< 25 (N=35) or BMI ≥ 30 (N=35)
* Seeking fertility treatment at the Arkansas Fertility and Gynecology Associates Clinic
* Assisted reproduction will include the oocyte retrieval technique
* 18 to 38 years of age

Exclusion Criteria

* Any health condition or medication that may interfere with the study outcome as determined by the investigators

Minimum Eligible Age

18 Years

Maximum Eligible Age

38 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Responsible Party

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Responsibility Role SPONSOR

Locations

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Arkansas Children's Nutrition Center

Little Rock, Arkansas, United States

Site Status

Countries

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United States

References

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Ruebel ML, Cotter M, Sims CR, Moutos DM, Badger TM, Cleves MA, Shankar K, Andres A. Obesity Modulates Inflammation and Lipid Metabolism Oocyte Gene Expression: A Single-Cell Transcriptome Perspective. J Clin Endocrinol Metab. 2017 Jun 1;102(6):2029-2038. doi: 10.1210/jc.2016-3524.

Reference Type DERIVED

PMID: 28323970 (View on PubMed)

Other Identifiers

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131386

Identifier Type: -

Identifier Source: org_study_id