Sex Differences in Gene Expression in Human Adipose Tissue

NCT ID: NCT00677651

Last Updated: 2009-08-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-04-30

Study Completion Date

2009-08-31

Brief Summary

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This project was created to assess sex differences in adipose tissue gene expression in different locations in the body. The primary objectives are to understand:

1. The mechanisms of differential body fat distribution in men and women
2. How body fat distribution is affected by reproductive hormones
3. The mechanisms linking fat distribution to health risks such as diabetes

Detailed Description

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Conditions

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Healthy Obesity

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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1

Five caucasian women

Adipose Biopsy

Intervention Type PROCEDURE

Adipose tissue will be sampled from the abdomen and buttock

Blood sample

Intervention Type PROCEDURE

Blood will be sampled from an IV line

CT Scan

Intervention Type RADIATION

Single image at the level of the liver

DEXA

Intervention Type RADIATION

Whole body scan

2

Five caucasian men

Adipose Biopsy

Intervention Type PROCEDURE

Adipose tissue will be sampled from the abdomen and buttock

Blood sample

Intervention Type PROCEDURE

Blood will be sampled from an IV line

CT Scan

Intervention Type RADIATION

Single image at the level of the liver

DEXA

Intervention Type RADIATION

Whole body scan

Interventions

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Adipose Biopsy

Adipose tissue will be sampled from the abdomen and buttock

Intervention Type PROCEDURE

Blood sample

Blood will be sampled from an IV line

Intervention Type PROCEDURE

CT Scan

Single image at the level of the liver

Intervention Type RADIATION

DEXA

Whole body scan

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* Caucasian men and women 20-35 years of age
* Lean (BMI less than 25)
* Obese (BMI 30-35)

Exclusion Criteria

* Hormonal birth control
* Pregnancy
* Smokers
* History of diabetes, kidney, liver or thyroid disease
* History of cancer
Minimum Eligible Age

20 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Maryland

OTHER

Sponsor Role collaborator

University of California, San Diego

OTHER

Sponsor Role lead

Responsible Party

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University of California, San Diego

Principal Investigators

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Jeffrey Chang, M.D.

Role: PRINCIPAL_INVESTIGATOR

UCSD

Locations

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UCSD

La Jolla, California, United States

Site Status

Countries

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United States

Other Identifiers

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070668

Identifier Type: -

Identifier Source: org_study_id

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