Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
30 participants
INTERVENTIONAL
2024-03-15
2024-12-30
Brief Summary
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The main questions to answer,
\- is there differences in the adipose tissue extracellular matrix in obese compared to young men is there differences in the adipose tissue extracellular matrix in old compared to young men
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Detailed Description
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After verbal and written information is provided signed consent is obtained.
Subjects arrive at the lab overnight fasted and not having done exercise the prior day and having consumed a normal isocaloric carbohydrate rich diet.
After a voiding and a 15 min rest body composition is determined by DXA. After this blood pressure is measured in the supine position in triplicate separated by 1 min. Following this a venous blood sample is obtained from a cubital vein, and kept on ice until further handling.
Subsequently an adipose tissue biopsy is obtained by the Bergström technique applied with suction from an incision 3-5 cm lateral from the umbilicus. After compression and a 30 min rest, the subject perform an incremental exercise test to determine maximal fat oxidation. In brief pulmonary oxygen uptake and carbon dioxide excretion is measured using a COSMED Quark B2 on-line system during 5 min rest sitting on a cycle ergometer, and then during exercise with 3 min increments starting at 60 Watt and increasing by 35 watts. When the respiratory exchange ratio is above 1 the exercise is stopped. After a 5 min break an incremental test until voluntary exhaustion is performed to determine maximal oxygen uptake. This completes the experiment.
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Young obese men
BMI \[30, 40\] Age \[18, 35\]
Cross sectional study
Physiological testing, Sampling of blood and abdominal adipose tissue and respiratory measurements at rest and during exercise
Young healthy men
BMI \[20, 25\] Age \[18, 35\]
Cross sectional study
Physiological testing, Sampling of blood and abdominal adipose tissue and respiratory measurements at rest and during exercise
Old healthy men
BMI \[20, 25\] Age \[60, 75\]
Cross sectional study
Physiological testing, Sampling of blood and abdominal adipose tissue and respiratory measurements at rest and during exercise
Interventions
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Cross sectional study
Physiological testing, Sampling of blood and abdominal adipose tissue and respiratory measurements at rest and during exercise
Eligibility Criteria
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Inclusion Criteria
* Obese men aged \[18,35\] and BMI \[30,40\]
* Healthy older men aged \[60,75\] and BMI \[20,25\]
Exclusion Criteria
* Consumption of medications and supplements that influence substrate use at rest and/or during exercise
18 Years
75 Years
MALE
Yes
Sponsors
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University of Copenhagen
OTHER
Responsible Party
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Jørn Wulff Helge
Professor
Principal Investigators
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Jørn W Helge, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Copenhagen
Locations
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Xlab, Faculty of Health and Medical Sciences, University of Copenhagen
Copenhagen, , Denmark
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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514-0894/23-3000
Identifier Type: -
Identifier Source: org_study_id
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