Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2015-06-30
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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MA
Middle-aged overweight and obese men (age 25-40yr)
Overfeeding
Consumption of 40% excess calories for 7 consecutive days
OA
Older overweight and obese men (age 55-75yr)
Overfeeding
Consumption of 40% excess calories for 7 consecutive days
Interventions
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Overfeeding
Consumption of 40% excess calories for 7 consecutive days
Eligibility Criteria
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Inclusion Criteria
* Aged 25-40y OR 55-75y
* BMI 28-35 kg/m2
* Weight stable (±2kg over past 3 mo)
* Sedentary to moderately active (\<3 d/wk of exercise lasting \>20min)
* Non-smokers (never used or quit \>7yrs prior)
Exclusion Criteria
* Currently using hormones, glucose or lipid lowering medication
* Engaged in exercise or diet program
* Currently gaining or losing weight or using weight loss drugs
* Diabetes mellitus (diagnosis, treatment, FBG ≥126 mg/dL)
* Uncontrolled metabolic disorders (e.g., thyroid)
25 Years
75 Years
MALE
Yes
Sponsors
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Colorado State University
OTHER
University of Colorado, Denver
OTHER
Responsible Party
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Principal Investigators
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Rachael E Van Pelt, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Colorado, Denver
Locations
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Univeristy of Colorado, Anschutz Medical Campus
Aurora, Colorado, United States
Countries
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References
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Kim JY, van de Wall E, Laplante M, Azzara A, Trujillo ME, Hofmann SM, Schraw T, Durand JL, Li H, Li G, Jelicks LA, Mehler MF, Hui DY, Deshaies Y, Shulman GI, Schwartz GJ, Scherer PE. Obesity-associated improvements in metabolic profile through expansion of adipose tissue. J Clin Invest. 2007 Sep;117(9):2621-37. doi: 10.1172/JCI31021.
Caso G, McNurlan MA, Mileva I, Zemlyak A, Mynarcik DC, Gelato MC. Peripheral fat loss and decline in adipogenesis in older humans. Metabolism. 2013 Mar;62(3):337-40. doi: 10.1016/j.metabol.2012.08.007. Epub 2012 Sep 19.
Tchoukalova YD, Votruba SB, Tchkonia T, Giorgadze N, Kirkland JL, Jensen MD. Regional differences in cellular mechanisms of adipose tissue gain with overfeeding. Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18226-31. doi: 10.1073/pnas.1005259107. Epub 2010 Oct 4.
Other Identifiers
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14-2411
Identifier Type: -
Identifier Source: org_study_id
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