Cold Stress Stimulate the Browing of Subcutaneous White Adipose in Healthy Adults

NCT ID: NCT02159144

Last Updated: 2015-08-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

10 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-30

Study Completion Date

2014-09-30

Brief Summary

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Adipose tissues, which include white adipose tissue (WAT) and brown adipose tissue (BAT), play an essential role in regulating whole-body energy homeostasis. Recent studies also reveal the presence of a subset of cells in WAT that could be induced by environmental or hormonal factors to become ''brown-like'' cells, and this ''beigeing'' process has been suggested to have strong antiobesity and antidiabetic benefits. More recently, same studies showed that cold stress stimulate the browning of subcutaneous white adipose. However, to the investigators knowledge, there are no direct data that clearly show that cold stress can promote the browning of subcutaneous white adipose.

Detailed Description

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Individuals have cold exposure at 15C for 2 hr everyday for one week.Biopsy for subcutaneous white adipose was performed before and after one week cold exposure programme under local anesthesia. Measure the brown fat characteristics of biopsy samples. The expression levels of uncoupling protein-1 (UCP-1), peroxisome proliferator-activated receptor (PPAR)-r, peroxisome proliferator-activated receptor r coactivator 1 a (PGC1a) , growth factor receptor binding protein-10 (Grb10), PR domain containing 16 (PRDM16) will be determined before and after cold stress programme from the biopsy samples. In addition, a combination of PET and computed tomography (CT) - with the glucose analogue 18F-fluorodeoxyglucose (18F-FDG) as a tracer will be performed for brown adipose tissue before and after cold stress programme.

Conditions

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Obesity Type 2 Diabetes

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Blinding Strategy

NONE

Study Groups

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healthy adults

Group Type EXPERIMENTAL

cold stress

Intervention Type OTHER

Interventions

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cold stress

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* healthy men
* 18-60 years old
* BMI 20-28 kg/m2

Exclusion Criteria

* BMI \< 20 kg/m2
* BMI \> 28 KG/M2
* Female
Minimum Eligible Age

20 Years

Maximum Eligible Age

60 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Xiang Guang-da

OTHER

Sponsor Role lead

Responsible Party

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Xiang Guang-da

Director of Endocrinology Department

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Wuhan General Hospital

Wuhan, Hubei, China

Site Status

Countries

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China

Other Identifiers

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2014Wze088

Identifier Type: -

Identifier Source: org_study_id

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