Adipose Cellular Kinetics of Lipedema

NCT ID: NCT05394467

Last Updated: 2025-03-17

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 24 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2022-04-07
• Study Completion Date: 2025-12-31

Brief Summary

Lipedema is characterized by an abnormal deposition of adipose tissue, resulting in fluid accumulation, limb enlargement, and pain. Lipedema is often misdiagnosed as simply obesity. A major challenge with diagnosis is the poorly understood biology underlying the disease. Limited studies suggest that the development of lipedema may involve adipocyte hypertrophy, increased commitment of adipose progenitor cells, hypoxia, adipocyte necrosis and macrophage recruitment. There remains an urgent need to investigate novel characteristics of adipose remodeling that may contribute to the pathogenesis of lipedema. The study investigators have reported quantitative measures of in vivo adipose kinetics using an 8-week incorporation of deuterium (administered as 2H2O) into the adipose tissue of women with obesity. The objective of this proposal is to utilize the metabolic 2H-labeling approach to measure, for the first time, in vivo adipocyte formation and triglyceride synthesis in the adipose tissue of participants with lipedema. Imaging approaches will provide a range of measurements to characterize the lipedema depots. The investigators hypothesize that lipedema adipose depots will have higher rates of adipocyte formation and triglyceride synthesis than both non-lipedema depots and those of women with traditional obesity. Lipedema may involve adipose tissue remodeling, characterized by adipocyte hypertrophy and increased commitment of preadipocytes and differentiation of adipocytes (adipogenesis), yielding an abundance of adipocytes with limited capacity to expand and accommodate lipid, resulting in hypoxia, macrophage recruitment, and local/systemic inflammation. Findings from this proposal will contribute to a better understanding of the pathogenesis of lipedema and may provide insight for the future development of therapeutic targets.

Conditions

Lipedema

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

Lipedema

Women with diagnosed lipedema

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• BMI ≤50 kg/m2
• Waist/hip ratio <0.86 (standing position)
• Clinical diagnosis of lipedema (mostly Stage 3 but Stage 2 will not be excluded)
• Willing to drink deuterated water (2H2O)

Exclusion Criteria

• Have major organ disease (heart, kidney, lung, thyroid, liver) or abnormal liver enzymes that represent a problem for study inclusion
• Chronic use of systemic glucocorticoids, atypical anti-psychotic medications, or medications that cause clinically significant changes in weight
• Pregnancy or breastfeeding in the next 3 months
• Partial and/or full hysterectomy (due to estrogen effects on adipogenesis)
• PCOS
• Self-reported positive test for HIV, hepatitis B and hepatitis C
• Smoking or use of tobacco products in the last 6 months
• Any medical, psychiatric or behavioral factors that may interfere with study participation

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 45 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: No

Sponsors

Lipedema Foundation

OTHER

Sponsor Role: collaborator

Pennington Biomedical Research Center

OTHER

Sponsor Role: lead

Responsible Party

Ursula White

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Ursula White, PhD

Role: CONTACT

ursula.white@pbrc.edu

2257632656

Eric Ravussin, PhD

Role: CONTACT

eric.ravussin@pbrc.edu

Facility Contacts

Ursula White, PhD

Role: primary

ursula.white@pbrc.edu

2257632656

Other Identifiers

PBRC 2021-051

Identifier Type: -

Identifier Source: org_study_id