Immune Characterization of Subcutaneous Adipose Tissue

NCT ID: NCT02076087

Last Updated: 2017-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

19 participants

Study Classification

OBSERVATIONAL

Study Start Date

2014-02-28

Study Completion Date

2017-09-30

Brief Summary

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The overall goal of this proposal is to characterize the immune cell profile of subcutaneous abdominal adipose tissue in lean, overweight, obese and lipedema adults, and to evaluate potential associations between different adipose tissue immune cell types and metabolic profile.

Detailed Description

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Conditions

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Determine Immune Cell Types in Subcutaneous Adipose Tissue

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Normal Weight (BMI: 18.5-24.9 kg/m²)

Liposuction/lipectomy

Liposuction/lipectomy

Intervention Type PROCEDURE

Subcutaneous adipose tissue will be obtained from liposuction/lipectomy to determine the types of immune cells

Overweight (BMI: 25.0-29.9 kg/m²)

Liposuction/lipectomy

Liposuction/lipectomy

Intervention Type PROCEDURE

Subcutaneous adipose tissue will be obtained from liposuction/lipectomy to determine the types of immune cells

Obese (BMI: >30.0kg/m²)

Liposuction/lipectomy

Liposuction/lipectomy

Intervention Type PROCEDURE

Subcutaneous adipose tissue will be obtained from liposuction/lipectomy to determine the types of immune cells

Interventions

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Liposuction/lipectomy

Subcutaneous adipose tissue will be obtained from liposuction/lipectomy to determine the types of immune cells

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Women of all races and ethnicity
* Age between 18 and 65 years
* Body Mass Index (BMI) ≥ 18.5 kg/m²
* Weight stable (+/- 3% during the last 2 months before enrollment)
* Women already scheduled for above mentioned procedures

Exclusion Criteria

* Diabetes Mellitus
* Recent (\<5 years) history of cancer (except in situ ductal breast carcinoma)
* Chemotherapy and/or radiation therapy within 4 months before enrollment
* Immune system diseases (i.e., autoimmune disorders, acquired immunodeficiency syndrome)
* Pregnant or breastfeeding
* Take any medication that might affect immune function
* Severe organ dysfunction
* BMI \<18.5 kg/m² or size of each breast is \>600 grams, if scheduled for bilateral breast reconstruction
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Washington University School of Medicine

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Samuel Klein, MD

Role: PRINCIPAL_INVESTIGATOR

Washington University School of Medicine

Locations

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Washington University School of Medicine

St Louis, Missouri, United States

Site Status

Countries

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United States

Other Identifiers

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2013-02113

Identifier Type: -

Identifier Source: org_study_id

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